The second cabinet of Manolache Costache Epureanu was the government of Romania from 27 April 1876 to 23 July 1876.

The ministers of the cabinet were as follows:^[1]

• President of the Council of Ministers:

• Manolache Costache Epureanu (27 April - 23 July 1876)

• Minister of the Interior:

• George Vernescu (27 April - 23 July 1876)

• Minister of Foreign Affairs:

• Mihail Kogălniceanu (27 April - 23 July 1876)

• Minister of Finance:

• Ion C. Brătianu (27 April - 23 July 1876)

• Minister of Justice:

• Mihail Pherekyde (27 April - 23 July 1876)

• Minister of War:

• Col. Gheorghe Slăniceanu (27 April - 23 July 1876)

• Minister of Religious Affairs and Public Instruction:

• Gheorghe Chițu (27 April - 23 July 1876)

• Minister of Public Works:

• Manolache Costache Epureanu (27 April - 23 July 1876)