Seraticin

Seraticin

Seraticin

Antibiotic substance

Seraticin is an antibiotic discovered by scientists at Swansea University able to inhibit 12 different strains of methicillin-resistant Staphylococcus aureus (MRSA), as well as E. coli and C. difficile. The research was funded by the charity Action Medical Research, with support from the Rosetrees Trust. Seraticin was isolated as a compound of less than 500 Da molecular weight from the maggot secretions of the common green bottle fly (Lucilia sericata)[1][2][3] It was patented in 2010 and has the molecular formula C
10H
16N
6O
9, but its chemical identity is unknown.[4]

Quick Facts Identifiers, Properties ...

It is speculated that mechanism of action for seraticin is inhibition of septal formation and cell division.[5]: 162 

References

  1. [1]
    "Multi-Tasking Maggots In Superbug Showdown". ScienceDaily. 11 August 2012. Retrieved 8 December 2012.
  2. [2]
    Bexfield A, Bond AE, Roberts EC, et al. (April 2008). "The antibacterial activity against MRSA strains and other bacteria of a <500 Da fraction from maggot excretions/secretions of Lucilia sericata (Diptera: Calliphoridae)". Microbes Infect. 10 (4): 325–33. doi:10.1016/j.micinf.2007.12.011. PMID 18400544.
  3. [3]
    Nigam, Yamni (2017-01-10). "Creepy, crawly maggots are actually a medical powerhouse". The Conversation. Retrieved 2023-12-04.
  4. [4]
    "(WO2011042684) Antimicrobial Composition and a Method of Controlling Contamination and Infection Using Said Composition". US Patent. October 1, 2010. Retrieved 8 December 2012.
  5. [5]
    Nigam, Yamni; Wilson, Michael R. (2022-07-18), "9. The Antimicrobial Activity of Medicinal Maggots", A Complete Guide to Maggot Therapy, Cambridge, UK: Open Book Publishers, pp. 153–174, doi:10.11647/obp.0300.09, ISBN 978-1-80064-728-2
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