Manitou is a town in Tillman County, Oklahoma, United States. The population was 171 as of the 2020 United States census.^[4] It includes the former town of Siboney, absorbed on January 28, 1907.^[5]

According to the United States Census Bureau, the town has a total area of 0.3 square miles (0.78 km²), all land.

Lake Frederick is approximately seven miles east.^[6]

As of the census^[3] of 2000, there were 278 people, 84 households, and 57 families residing in the town. The population density was 883.0 inhabitants per square mile (340.9/km²). There were 111 housing units at an average density of 352.6 per square mile (136.1/km²). The racial makeup of the town was 81.29% White, 8.99% African American, 3.60% Native American, 0.36% Asian, 0.36% Pacific Islander, 1.08% from other races, and 4.32% from two or more races. Hispanic or Latino of any race were 7.91% of the population.

There were 84 households, out of which 31.0% had children under the age of 18 living with them, 56.0% were married couples living together, 8.3% had a female householder with no husband present, and 32.1% were non-families. 31.0% of all households were made up of individuals, and 17.9% had someone living alone who was 65 years of age or older. The average household size was 2.52 and the average family size was 3.21.

In the town, the population was spread out, with 44.2% under the age of 18, 5.8% from 18 to 24, 19.1% from 25 to 44, 18.7% from 45 to 64, and 12.2% who were 65 years of age or older. The median age was 25 years. For every 100 females, there were 167.3 males. For every 100 females age 18 and over, there were 93.8 males.

The median income for a household in the town was $33,036, and the median income for a family was $35,750. Males had a median income of $23,750 versus $12,321 for females. The per capita income for the town was $9,177. About 13.8% of families and 25.9% of the population were below the poverty line, including 47.8% of those under the age of eighteen and 16.0% of those 65 or over.

Manitou is served by U.S. Route 183, and is the eastern terminus of State Highway 5C.^[8]

Frederick Regional Airport (KFDR; FAA ID: FDR), with a 6099 x 150 ft. paved runway, is approximately 11 miles south of town.^[9]

Commercial air transportation is available out of Lawton-Fort Sill Regional Airport, about 38 miles to the east,^[10] or the larger Will Rogers World Airport in Oklahoma City, about 121 miles northeast.^[11]

The Southwest Oklahoma Juvenile Center of the Oklahoma Office of Juvenile Affairs is located in Manitou.^[12]