Kadampanad church is one of the oldest churches of St. Thomas Christians in Kerala. Mar Thoma Sliha (St. Thomas), an Apostle of Jesus Christ, came to India in AD 52 and established a Christian community in Kerala. There is evidence that he established eight churches (known as Ezharapallikal). One among them was at Chayal (Nilackel), situated in the western ghats. In the beginning of the fourth century, a group of Syrian Christians from Chayal migrated to Kadampanad. They consecrated a church at Kadampanad in accordance with Syrian tradition and rituals in AD 325, in the name of Mar Thoma Sliha as their patron saint. As time went by, a strong Syrian Christian community flourished in the vicinity of this church.
This church has been rebuilt several times. According to tradition the reconstructions took place roughly around AD 800, AD 1200, AD 1800, AD 1912 and finally in 1952. There has been a subsequent migration of Syrian Christians from Nilackel during the period of the 12th century and later at the early half of the 14th century due to demolition of Nilackel Church (supposedly due to floods).
This church is considered to be the mother church of many parishes in Central Travancore. The descendants of those who settled down in Kadampanad, later migrated to places like Mavelikkara, Kayamkulam, Kollakadavu, Adoor, Kozhenchery, Kaippattoor, Sooranadu, Kallada, Koodal etc., settled there and constructed new churches.
Saint Geevarghese Mar Gregorios (Parumala Thirumeni) oversaw the progress of the Church in 1895.