Streptomyces_avermitilis

<i>Streptomyces avermitilis</i>

Streptomyces avermitilis

Species of bacterium

Streptomyces avermitilis is a species of bacteria in the genus Streptomyces. This bacterium was discovered by Satoshi Ōmura in Shizuoka Prefecture, Japan.

Quick Facts Streptomyces avermitilis, Scientific classification ...

The first complete genome sequence of S. avermitilis was completed in 2003.[4] The genome consists of a single chromosome with a linear structure, unlike most bacterial genomes, which exist in the form of circular chromosomes.[5]

Avermectins are industrially derived from the fermentation products of S. avermitilis.[1][6] Avermectin itself was discovered by the Satoshi Ōmura group[6] and first disclosed in Burg et al. 1979.[1] One of the most widely employed drugs against nematode and arthropod infestations is the avermectin derivative ivermectin, as well as abamectin, a widely used insecticide and antihelmintic.

See also

References

  1. [1]
    Burg, R. W.; Miller, B. M.; Baker, E. E.; Birnbaum, J.; Currie, S. A.; Hartman, R.; Kong, Y. L.; Monaghan, R. L.; Olson, G.; Putter, I.; Tunac, J. B.; Wallick, H.; Stapley, E. O.; Oiwa, R.; Omura, S. (1979). "Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation". Antimicrobial Agents and Chemotherapy. 15 (3): 361–367. doi:10.1128/AAC.15.3.361. PMC 352666. PMID 464561.
  2. [2]
    Kim, S. B.; Goodfellow, M. (2002). "Streptomyces avermitilis sp. nov., nom. Rev., a taxonomic home for the avermectin-producing streptomycetes". International Journal of Systematic and Evolutionary Microbiology. 52 (Pt 6): 2011–2014. doi:10.1099/ijs.0.02265-0. PMID 12508861.
  3. [3]
    Takahashi, Y.; Matsumoto, A.; Seino, A.; Ueno, J.; Iwai, Y.; Omura, S. (2002). "Streptomyces avermectinius sp. nov., an avermectin-producing strain". International Journal of Systematic and Evolutionary Microbiology. 52 (Pt 6): 2163–2168. doi:10.1099/ijs.0.02237-0. PMID 12508884.
  4. [4]
    Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Kikuchi H, Shiba T, Sakaki Y, Hattori M, Omura S (2003). "Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis". Nat. Biotechnol. 21 (5): 526–531. doi:10.1038/nbt820. PMID 12692562.
  5. [5]
    Paul Dyson (1 January 2011). Streptomyces: Molecular Biology and Biotechnology. Horizon Scientific Press. p. 5. ISBN 978-1-904455-77-6. Retrieved 16 January 2012.
  6. [6]
    Martín, Juan F; Rodríguez-García, Antonio; Liras, Paloma (2017-03-15). "The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis". The Journal of Antibiotics. 70 (5). Japan Antibiotics Research Association (Nature Portfolio): 534–541. doi:10.1038/ja.2017.19. ISSN 0021-8820. PMID 28293039. S2CID 1881648.
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