TRNA_(adenine9-N1)-methyltransferase

TRNA (adenine9-N1)-methyltransferase

TRNA (adenine9-N1)-methyltransferase

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TRNA (adenine9-N1)-methyltransferase (EC 2.1.1.218, Trm10p, tRNA(m1G9/m1A9)-methyltransferase, tRNA(m1G9/m1A9)MTase, TK0422p (gene), tRNA m1A9-methyltransferase, tRNA m1A9 Mtase) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (adenine9-N1)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine9 in tRNA S-adenosyl-L-homocysteine + N1-methyladenine9 in tRNA
Quick Facts 9-N1)-methyltransferase, Identifiers ...

The enzyme from Sulfolobus acidocaldarius specifically methylates adenine9 in tRNA.

References

  1. [1]
    Kempenaers M, Roovers M, Oudjama Y, Tkaczuk KL, Bujnicki JM, Droogmans L (October 2010). "New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA". Nucleic Acids Research. 38 (19): 6533–43. doi:10.1093/nar/gkq451. PMC 2965216. PMID 20525789.
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