TRNA_(guanine10-N2)-methyltransferase

TRNA (guanine10-N2)-methyltransferase

TRNA (guanine10-N2)-methyltransferase

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TRNA (guanine10-N2)-methyltransferase (EC 2.1.1.214, (m2G10) methyltransferase, Trm11-Trm112 complex) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (guanine10-N2)-methyltransferase.[1] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + guanine10 in tRNA S-adenosyl-L-homocysteine + N2-methylguanine10 in tRNA
Quick Facts 10-N2)-methyltransferase, Identifiers ...

tRNA (guanine10-N2)-methyltransferase from yeast does not catalyse the methylation from N2-methylguanine10 to N2-dimethylguanine10 in tRNA.

References

  1. [1]
    Purushothaman SK, Bujnicki JM, Grosjean H, Lapeyre B (June 2005). "Trm11p and Trm112p are both required for the formation of 2-methylguanosine at position 10 in yeast tRNA". Molecular and Cellular Biology. 25 (11): 4359–70. doi:10.1128/MCB.25.11.4359-4370.2005. PMC 1140639. PMID 15899842.
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