TUBA4A

TUBA4A

TUBA4A

Protein-coding gene in the species Homo sapiens

Tubulin alpha-4A chain is a protein that in humans is encoded by the TUBA4A gene.[5]

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Function

Microtubules of the eukaryotic cytoskeleton perform essential and diverse functions and are composed of a heterodimer of alpha and beta tubulin. The genes encoding these microtubule constituents are part of the tubulin superfamily, which is composed of six distinct families. Genes from the alpha, beta and gamma tubulin families are found in all eukaryotes. The alpha and beta tubulins represent the major components of microtubules, while gamma tubulin plays a critical role in the nucleation of microtubule assembly. There are multiple alpha and beta tubulin genes and they are highly conserved among and between species. This gene encodes an alpha tubulin that is a highly conserved homolog of a rat testis-specific alpha tubulin.[6]

Interactions

TUBA4A has been shown to interact with NCOA6[7] and APC.[8]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000127824 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000026202 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Villasante A, Wang D, Dobner P, Dolph P, Lewis SA, Cowan NJ (Jul 1986). "Six mouse alpha-tubulin mRNAs encode five distinct isotypes: testis-specific expression of two sister genes". Molecular and Cellular Biology. 6 (7): 2409–19. doi:10.1128/mcb.6.7.2409. PMC 367794. PMID 3785200.
  6. [6]
    "Entrez Gene: TUBA4A tubulin, alpha 4a".
  7. [7]
    Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW (Jan 2003). "Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins". Molecular and Cellular Biology. 23 (1): 140–9. doi:10.1128/MCB.23.1.140-149.2003. PMC 140670. PMID 12482968.
  8. [8]
    Zumbrunn J, Kinoshita K, Hyman AA, Näthke IS (Jan 2001). "Binding of the adenomatous polyposis coli protein to microtubules increases microtubule stability and is regulated by GSK3 beta phosphorylation". Current Biology. 11 (1): 44–9. doi:10.1016/S0960-9822(01)00002-1. PMID 11166179. S2CID 15004529.

Further reading

This article incorporates text from the United States National Library of Medicine, which is in the public domain.

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