The Tartu University Clinic (Estonian: Tartu Ülikooli Kliinikum) is a healthcare and medical teaching service in Tartu, Estonia, and a subsidiary of the Tartu University. Its administrative services are located in two buildings on Puusepa Street; its buildings are located throughout the city of Tartu. As an exception, the Clinic's andrology clinic has a facility in Tallinn, on Gonsiori Street.

The clinic had a pioneering role in the study of mental illnesses, as it was the world's first university clinic with a psychiatry department.^[1] Famous German psychiatrist Emil Kraepelin worked there.^[2]

The surgery of the clinic is connected with works of famous Russian surgeons Nikolay Pirogov^[3] (worked there in 1836–1840) and Nikolai Burdenko^[4] (worked there in 1906–1918).

The Tartu University Hospital, also known as Tartu Hospital, located at 8 Puusepa Street, is a part of the Tartu University Clinic.