In 1982, Oleske is practicing medicine at Newark, New Jersey's New Jersey Medical School when he discovers several of his pediatric patients failing to thrive and suffering from what appears to be suppressed immune systems. Most of his patients are impoverished inner city African Americans and Hispanics who are either intravenous drug users or the heterosexual partners thereof. His efforts to convince the Centers for Disease Control (CDC) that AIDS is the cause of this threat falls on largely deaf and hesitant ears, while another doctor asks him about whether or not Bible belt politicians will enjoy having to tell their voters that their taxes are being spent on homosexuals and I.V. drug users living in the largely liberal coastal cities where most AIDS cases were and still are reported from.
Later, he receives a report from the CDC about infected transfusions and blood products and finds one of his pediatric patients had received blood from a donor who later developed and died of the disease, much to the anger of the patient's family over not being told this beforehand. TV reporters appear in the hospital wearing disposable latex gloves, surgical clothes and masks, afraid of becoming infected by being in the same room or building with Oleske and his AIDS patients.
Another of his patients, an adult female former prostitute and I.V. drug user, is informed by him that her child has the disease, indicating that its virus was passed to her child through her blood while she was pregnant, meaning that she became infected before she gave up drugs and prostitution. After her child dies of AIDS, she returns to her former lifestyle.
The publicity of Oleske's work on AIDS also causes problems with his family in his private life as his children are subjected to ridicule from their peers about this. In 1984, when it's announced that the virus that causes AIDS has been isolated, another one of his child patients dies of AIDS and is buried in a Gospel music style funeral that Oleske attends, and Oleske finally receives approval of his work from the CDC and promises to continue his work among his patients, even though they will eventually die young.
