Thishiwe Ziqubu (born 5 August 1985) is a South African film director, writer and actor.^[1] He won Best Actress in a Supporting Role at the 2016 Africa Movie Academy Awards for his portrayal of Tshaka in the romantic comedy Tell Me Sweet Something.^[2] In 2019, he directed episodes of MTV Shuga Down South.

Ziqubu is a trans man and in a relationship with his partner Mandisa Nduna.^[3]

Ziqubu studied scriptwriting and directing after high school. He later attended the African Film and Drama Academy (AFDA), a film school. He also completed an Acting for Film programme at the Los Angeles campus of the New York Film Academy.^[1]

Ziqubu made his acting debut in the 2011 drama film Man on Ground, which helped to move his career forward. As a scriptwriter and director, he wrote and directed three independent short films: Out Of Luck, Subdued and Between the Lines.^[1] He has also written for South African television soap operas Isidingo and Rhythm City and for Is'Thunzi, a drama series. He co-created, wrote (as head writer) and directed a supernatural four-part drama series entitled Emoyeni.

In 2019, he directed episodes of the second season of TV series MTV Shuga Down South.^[4]