Thomas Ming Swi Chang, OC (born 8 April 1933) is a Chinese-born Canadian inventor, physician, and physiologist.

While an undergraduate at McGill University in 1957, Chang invented the world's first artificial cell. Working with improvised materials like perfume atomizers inside his dorm room turned laboratory, Chang managed to create a permeable plastic sack that would effectively carry haemoglobin almost as effectively as a natural blood cell.^[1] He went on to complete his B.Sc. (1957), M.D., C.M. (1961), and Ph.D (1965) degrees at McGill.^[2] Chang's career continued as founder and Director of the Artificial Cells and Organs Research Centre and Professor of Physiology, Medicine & Biomedical Engineering in the Faculty of Medicine at McGill University.^[1]

In the late 1960s he discovered enzymes carried by artificial cells could correct some metabolic disorders and also developed charcoal-filled cells to treat drug poisoning. His work on finding a safe blood substitute brought him to prominence in the 1980s and 1990s, earning him an Order of Canada.^[3] The Canadian Academy of Health Sciences states, "Dr. Chang’s original ideas were years ahead of the modern era of nanotechnology, regenerative medicine, gene therapy, stem cell/cell therapy and blood substitutes. He was nominated twice for the Nobel Prize".^[4]

In 2011, Dr. Chang was voted the winner of the Greatest McGillian contest organized by the McGill Alumni Association for McGill's 190th anniversary.^[5]