Wisconsin

U.S. Highway 53 begins at its southern terminus with a junction at U.S. 14, U.S. 61, and Wisconsin Highway 16 in downtown La Crosse. From there, U.S. 53 crosses Interstate 90 and becomes a freeway bypass of Onalaska and Holmen before proceeding north to Eau Claire as a two-lane roadway. The interchange with Interstate 94 at Eau Claire begins a freeway / expressway stretch for U.S. 53 north to the city limits of Superior. The c. 2006 freeway in Eau Claire bypasses most of the city, alleviating congestion on the original route (signed now as both Business U.S. 53 and Hastings Way). Business U.S. 53 / Hastings Way is a mix of grade-separated interchanges and at-grade intersections, and is routed through Eau Claire, passing within about one mile (1.6 km) of downtown Eau Claire. Other smaller towns between Eau Claire and Superior (Minong and Solon Springs) were bypassed in a similar manner.

Wisconsin's first single-point urban interchange is found along the U.S. 53 bypass of Eau Claire, at its interchange with U.S. 12 in Altoona.^[2] This interchange received the 2005 Outstanding Highway Construction award from the Bureau of Project Development.^[3]

U.S. 53 continues as a freeway north of Eau Claire past Chippewa Falls to Rice Lake, where it then becomes an expressway with only three grade-separated interchanges (one at 28th Avenue (CTH-V) in Haugen, one at Wisconsin Highway 70 near Spooner and one at Wisconsin Highway 13, immediately southeast of Superior). U.S. 53 has a partial grade-separated interchange with U.S. 2 in the town of Amnicon, but traffic turning from U.S. 2 westbound onto U.S. 53 southbound must take a U-turn at an at-grade crossover past the interchange.

After passing through the city of Superior as a four-lane city surface street (East Second Street) for a 5-mile (8.0 km) stretch, U.S. 53 then approaches the Saint Louis Bay. U.S. 53 then runs together with Interstate 535 and crosses the bay via the John Blatnik Bridge into Minnesota.

In 1989, the entirety of US 53 in Wisconsin was designated the Peace Memorial Highway, commemorating citizens of Wisconsin who have worked to promote international peace.^[4]

Minnesota

US 53 enters the state at the city of Duluth on the John Blatnik Bridge over the Saint Louis Bay. US 53 runs concurrently with I-535 for 2.8 miles (4.5 km) as it enters Minnesota. I-535/US 53 has an interchange with I-35 in Duluth, known locally as the "Can of Worms"; it features a pair of left exits from I-35, a stoplight and lane drops over the I-35 bridge.^[5]

After its junction with I-35, US 53 continues through Duluth on Piedmont Avenue and Trinity Road for 3.5 miles (5.6 km).

US 53 then runs concurrently with State Highway 194 (MN 194) for six miles (9.7 km), from Trinity Road in Duluth to Lindahl Road in the city of Hermantown. This four-lane stretch of US 53 and MN 194 are also known as the Miller Trunk Highway in the cities of Duluth and Hermantown.

From Hermantown, the route proceeds north to the city of Virginia. The portion of the route from Duluth to Virginia is a four-lane expressway. US 53 has a junction with MN 33 at the unincorporated community of Independence. Continuing northbound, US 53 has an interchange with US 169 in Virginia. In between the US 169 and MN 135 interchanges is the Thomas Rukavina Memorial Bridge. This bridge is the tallest in the state and spans 4 lanes of freeway. Immediately north of Virginia, US 53 has an interchange with MN 169 in Wuori Township.

US 53 then proceeds northwest to International Falls, where it has a junction with US 71 and MN 11.

US 53 in Minnesota passes through Saint Louis and Koochiching counties. Legally, the Minnesota section of US 53 is defined as unmarked legislative routes 106, 11, and 315 in Minnesota Statutes §§ 161.115(37), (246), and 161.114(2). US 53 is not marked with these legislative numbers along the actual highway.

Relocation between Eveleth and Virginia

On May 5, 2010, Cliffs Natural Resources provided notice to the Minnesota Department of Transportation (MnDOT) that U.S. Highway 53 easement rights across the United Taconite Mine, per a 1960 agreement, would be terminated to allow for expansion of the mine. United Taconite and MnDOT negotiated an agreement to move the roadway by 2017.^[15]

There were three rerouting options proposed:^[16]

• West – Following State Highway 37 and Saint Louis County Road 7.
• Center – Through the Auburn Pit; on the south side of the existing route of Highway 53.
• East – Around and across the Rouchleau Pit; on the north side of the existing route of Highway 53.

The East route was selected for the project and construction began in November 2015,^[17] with the realignment reaching completion in 2017. On September 15, the new roadway was opened, with a dedication of the bridge spanning the Rouchleau Pit. The bridge is the tallest in the state at 204 feet (62 m) in height.^[18]

Wisconsin

With the exception of a 5-mile (8.0 km) stretch as a four-lane city surface street (East Second Street) in the city of Superior, the entire route within Wisconsin is completed to freeway or expressway standards. On the south end of the corridor, the connection to Interstate Highway 94 is a 7.5-mile (12.1 km) stretch through the Eau Claire-Chippewa Falls conurbation. After years of legal and political wrangling, the decision was made in the late 1990s to bypass the current route, rather than to convert the present highway to freeway standards. The northern half of this bypass, as far south as WIS 312 was opened to traffic in mid-2005. The southern half of the bypass, which includes a pair of multilane bridges over the Eau Claire River, goes mostly through Altoona and includes interchanges with WIS 312, U.S. Highway 12 and WIS 93. This project won multiple awards in 2005 and 2006.^[3] This section of the bypass was opened mid-morning on August 21, 2006.

Minnesota

Federal funding for the project in northern Minnesota was $940,000 in 2003 and nearly $600,000 in 2004.^[19] At present, with the exception of 3.5 miles (5.6 km) stretch within the city of Duluth (Piedmont Avenue and Trinity Road), the route is completed as an expressway as far north as the city of Cook, leaving approximately 73 miles (117 km) of the route to International Falls to be converted to expressway standards.