U46619 is a stable synthetic analog of the endoperoxide prostaglandin PGH₂ first prepared in 1975,^[1] and acts as a thromboxane A₂ (TP) receptor agonist. It potently stimulates TP receptor-mediated, but not other prostaglandin receptor-mediated responses in various in vitro preparations and exhibits many properties similar to thromboxane A₂, including shape change and aggregation of platelets ^[2] and smooth muscle contraction. U46619 is a vasoconstrictor that mimics the hydroosmotic effect of vasopressin.^[3]

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U46619

Names
Preferred IUPAC name (5Z)-7-{(1R,4S,5S,6R)-6-[(1E,3S)-3-Hydroxyoct-1-en-1-yl]-2-oxabicyclo[2.2.1]heptan-5-yl}hept-5-enoic acid
Identifiers
CAS Number	56985-40-1 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL357834 N
ECHA InfoCard	100.164.944
IUPHAR/BPS	1888
PubChem CID	5311493
SMILES CCCCC[C@H](O)/C=C/[C@H]1[C@@H]2OC[C@@H](C2)[C@@H]1C/C=C\CCCC(O)=O
Properties
Chemical formula	C21H34O4
Molar mass	350.49 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

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