Ubiquitin-conjugating enzyme E2 D1 is a protein that in humans is encoded by the UBE2D1 gene.^[5][6][7]

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UBE2D1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2C4P, 2YHO, 3OJ4, 3PTF, 4AP4, 4QPL, 5FER
Identifiers
Aliases	UBE2D1, E2(17)KB1, SFT, UBC4/5, UBCH5, UBCH5A, ubiquitin conjugating enzyme E2 D1
External IDs	OMIM: 602961 MGI: 2384911 HomoloGene: 20714 GeneCards: UBE2D1
EC number	2.3.2.24
Gene location (Human) Chr. Chromosome 10 (human)[1] Band 10q21.1 Start 58,334,979 bp[1] End 58,370,751 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B5.3 Start 71,090,810 bp[2] End 71,121,092 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in biceps brachii vastus lateralis muscle right ventricle monocyte gastrocnemius muscle body of tongue thoracic diaphragm triceps brachii muscle amniotic fluid deltoid muscle Top expressed in interventricular septum triceps brachii muscle sternocleidomastoid muscle quadriceps femoris muscle temporal muscle skeletal muscle tissue ankle digastric muscle vastus lateralis muscle ganglionic eminence More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding ubiquitin conjugating enzyme activity ATP binding protein binding ubiquitin-protein transferase activity ubiquitin protein ligase binding Cellular component cytoplasm nucleoplasm cytosol ubiquitin ligase complex protein-containing complex Biological process protein K48-linked ubiquitination BMP signaling pathway protein polyubiquitination negative regulation of transcription by RNA polymerase II anaphase-promoting complex-dependent catabolic process positive regulation of protein ubiquitination ubiquitin-dependent protein catabolic process protein ubiquitination protein deubiquitination positive regulation of protein polyubiquitination protein targeting to peroxisome regulation of mitotic cell cycle phase transition MyD88-independent toll-like receptor signaling pathway TRIF-dependent toll-like receptor signaling pathway Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 7321 216080 Ensembl ENSG00000072401 ENSMUSG00000019927 UniProt P51668 P61080 RefSeq (mRNA) NM_003338 NM_001204880 NM_145420 RefSeq (protein) NP_001191809 NP_003329 NP_663395 Location (UCSC) Chr 10: 58.33 – 58.37 Mb Chr 10: 71.09 – 71.12 Mb PubMed search [3] [4]
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The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is closely related to a stimulator of iron transport (SFT), and is up-regulated in hereditary hemochromatosis. It also functions in the ubiquitination of the tumor-suppressor protein p53 and the hypoxia-inducible transcription factor HIF1alpha by interacting with the E1 ubiquitin-activating enzyme and the E3 ubiquitin-protein ligases.^[7]

UBE2D1 has been shown to interact with:

• BARD1,^{[8][9][10][11][12][13][14][15]}
• BRCA1,^{[8][9][10][11][12][13][14][15][16][17]} and
• UBE3A.^[18][19]