UDP-sulfoquinovose_synthase

UDP-sulfoquinovose synthase

UDP-sulfoquinovose synthase

Class of enzymes

UDP-sulfoquinovose synthase (EC 3.13.1.1) is an enzyme that catalyzes the chemical reaction

UDP-glucose + sulfite UDP-6-sulfoquinovose + H2O
Quick Facts UDPsulfoquinovose synthase, Identifiers ...

Thus, the two substrates of this enzyme are UDP-glucose and sulfite, whereas its two products are UDP-6-sulfoquinovose and H2O.[1]

In a subsequent reaction catalyzed by sulfoquinovosyl diacylglycerol synthase, the sulfoquinovose portion of UDP-sulfoquinovose is combined with diacyglycerol to produce the sulfolipid sulfoquinovosyl diacylglycerol (SQDG).[2]

This enzyme belongs to the family of hydrolases, specifically those acting on carbon-sulfur bonds. The systematic name of this enzyme class is UDP-6-sulfo-6-deoxyglucose sulfohydrolase. Other names in common use include sulfite:UDP-glucose sulfotransferase, and UDP-sulfoquinovose synthase. This enzyme participates in nucleotide sugars metabolism and glycerolipid metabolism.

The 3-dimensional structure of the enzyme is known from Protein Data Bank entries 1qrr (Mulichak et al., 1999), 1i24, 1i2b and 1i2c.

See also

References

  1. [1]
    Mulichak, AM; Theisen, MJ; Essigmann, B; Benning, C; Garavito, RM (9 November 1999). "Crystal structure of SQD1, an enzyme involved in the biosynthesis of the plant sulfolipid headgroup donor UDP-sulfoquinovose". Proceedings of the National Academy of Sciences of the United States of America. 96 (23): 13097–102. Bibcode:1999PNAS...9613097M. doi:10.1073/pnas.96.23.13097. PMC 23906. PMID 10557279.
  2. [2]
    Goddard-Borger, ED; Williams, SJ (20 February 2017). "Sulfoquinovose in the biosphere: occurrence, metabolism and functions". The Biochemical Journal. 474 (5): 827–849. doi:10.1042/BCJ20160508. PMID 28219973.


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