Ubiquitinyl_hydrolase_1

Ubiquitinyl hydrolase 1

Ubiquitinyl hydrolase 1

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Ubiquitinyl hydrolase 1 (EC 3.4.19.12, ubiquitin C-terminal hydrolase, yeast ubiquitin hydrolase) is an enzyme.[1][2] This enzyme catalyses the following chemical reaction

Thiol-dependent hydrolysis of ester, thioester, amide, peptide and isopeptide bonds formed by the C-terminal Gly of ubiquitin
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This enzyme hydrolyses links to polypeptides smaller than 60 residues faster than those to larger polypeptides.

References

  1. [1]
    Johnston SC, Larsen CN, Cook WJ, Wilkinson KD, Hill CP (July 1997). "Crystal structure of a deubiquitinating enzyme (human UCH-L3) at 1.8 A resolution". The EMBO Journal. 16 (13): 3787–96. doi:10.1093/emboj/16.13.3787. PMC 1170002. PMID 9233788.
  2. [2]
    Wilkinson, K.D.; Rawlings, N.D.; Woessner, J.F. (1998). "Ubiquitin C-terminal hydrolase". In Barrett, A.J. (ed.). Handbook of Proteolytic Enzymes. London: Academic Press. pp. 470–472.
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