West Lafayette Junior-Senior High School (also informally known as West Side High School or simply West Side^[2][3][4]) is the only high school within the West Lafayette city limits, and is administered by the West Lafayette Community School Corporation.

West Lafayette Junior-Senior High School was constructed in 1939 of cream brick and glass at a cost of $225,000, and was remodeled in the late 1990s. The school is located near Purdue University, and the children of many Purdue faculty and staff attend West Side.^[2][3] In 2012, the school was ranked as the 2nd and 4th best public high school in Indiana by U.S. News & World Report and Newsweek, respectively.^[5][6] As of 2021, the high school was ranked in U.S. News & World Report as 2nd in Indiana and 239th nationwide.^[7]

The school offers athletic programs including football, baseball, basketball, cheerleading, cross country, soccer, wrestling, golf, track and field, swimming, tennis and volleyball. The teams play under the nickname of the Red Devils and belong to the Hoosier Athletic Conference. The Red Devils have won 7 state championships.^[8]

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• Sonia Y. Angell (Class of 1983), public health leader
• Moungi Bawendi (Class of 1978), winner of the 2023 Nobel Prize in Chemistry and professor at MIT
• Katie Bouman (Class of 2007), imaging scientist
• Greg Christopher (Class of 1984), athletic director
• Neil Eggleston (Class of 1971), White House Counsel
• Paul Eremenko (Class of 1997), innovator and technology executive
• Bob Friend (Class of 1949), pitcher for the Pittsburgh Pirates
• Gen Fukunaga (Class of 1979), founder of Funimation Entertainment
• George Karlaftis (Class of 2019), NFL football player
• Tom Kelly (Class of 1967), songwriter
• Jay McDowell (Class of 1987), bassist for country music band BR549
• Gavin Mikhail (Class of 1991), singer-songwriter
• Sameer Mishra (Class of 2012), won the 81st Scripps National Spelling Bee
• Tom Moore (Class of 1961), director
• Toby Moskowitz (Class of 1989), financial economist
• Chike Okeafor (Class of 1994), NFL football player
• Eric Rodwell (Class of 1974), professional bridge player
• Carolyn Wood Sherif (Class of 1940), social psychologist
• Janet Tobias (Class of 1976), television producer
• Randy Truitt (Class of 1986), member of the Indiana House of Representatives
• Dan Wodicka (Class of 2010), winner of the 2009 Mr. Football Award (Indiana) and Johns Hopkins Blue Jays Football head coach^[9]

• List of high schools in Indiana