West Virginia Route 10 is a north–south route from Cabell County to Mercer County in the western and southern regions of West Virginia. Mostly a two-lane, winding highway with no shoulders, Route 10 is considered to be one of substandard design when compared to modern standards. Nevertheless, it serves as a major arterial highway in the state, carrying a substantial amount of traffic volume. Tractor-trailers have a particularly difficult time negotiating many of the route's sharp, hairpin curves.

Quick Facts Route information, Length ...

West Virginia Route 10
Route information
Maintained by WVDOH
Length	145 mi[1] (233 km)
Major junctions
South end	US 19 in Kegley
Major intersections	WV 16 between Mullens and Pineville WV 97 in Pineville WV 85 in Oceana WV 80 in Man WV 73 in Logan US 119 in Chapmanville WV 3 in West Hamlin I-64 at Huntington
North end	US 60 in Huntington
Location
Country	United States
State	West Virginia
Counties	Mercer, Wyoming, Logan, Lincoln, Cabell
Highway system
West Virginia State Highway System Interstate US State
← WV 9 → US 11

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Between the towns of West Hamlin and Man, most of the route closely parallels the course of the Guyandotte River. Thus, it follows a very winding course, with a solid rocks just inches from the roadway, and is thus very dangerous. An upgrade from Man to Logan to a four-lane highway built to the same standards as the Appalachian Corridor System was completed the first part of September 2017. From Man to Lacoma, the route follows Huff Creek, then turns south to Oceana. Then it follows a south-eastern path parallel to several small streams and terminates into US 19 just north of Princeton, West Virginia.

In Huntington, portions of the highway are named Troy Brown Way and Hal Greer Boulevard in honor of two notable local professional athletes.

West Virginia Route 10 Alternate is a four-mile-long north–south road near Barboursville, West Virginia connecting WV 10 to the south and US 60 to the north. It acts as an alternative route to Huntington and eliminates many of the curves that plague WV 10 south of Interstate 64 to the WV 10 Alternate junction.