William Entwisle (30 September 1808 – 18 August 1865)^[1] was a British Conservative politician.^[2]

Born in Manchester, Entwisle was the fourth son of Richard Entwisle. At age 19, he was admitted as a pensioner at Trinity College, Cambridge before matriculating in Michaelmas in 1827, and then becoming a scholar in 1830. He graduated as a Bachelor of Arts and as 20th wrangler in 1831, and as a Master of Arts in 1834. He was also admitted to Lincoln's Inn in 1831, and was called to the Bar in 1836.^[2]

He became an honorary Doctor of Civil Law at the University of Oxford in 1844, and was also a chairman of the Manchester and Leeds Railway Company, and a partner at banking firm Loyd, Entwisle, Bury and Jervis, now part of the Royal Bank of Scotland. At some point, he married Hannah Loyd, daughter of Edward Loyd, a banker at the firm, and they had at least one son, named William.^[2]

He was elected Conservative Member of Parliament for South Lancashire at a by-election in 1844—caused by the death of Richard Bootle-Wilbraham— and held the seat until 1847 when he did not seek re-election.^[3][2]

Entwisle died in 1865 at Hanford, near Blandford in Dorset.^[2]