Mooney

Vanderbilt opened the season on September 24 with a defeat of Mooney School 34–0.^{[n 1]} Ray Morrison and Bill Neely starred in the backfield.^[15] Despite the excessive heat,^[16] newcomers Kent Morrison, Enoch Brown, and Hugh Morgan played well.^[16]

The starting lineup was E. Brown (left end), Stegall (left tackle), Metzger (left guard), Morgan (center), Ridgeway (right guard), Freeland (right tackle), Covington (right end), Morrison (quarterback), Neely (left halfback), Williams (right halfback), Robbins (fullback).^[15]

Rose Polytechnic

Vanderbilt won over Rose Polytechnic, 23–0. Morrison and Neely again starred in the swift backfield.^[17] Ted Ross re-injured his knee.^[16] Taking Ross's place in the line was Tom Brown.^[16]

The starting lineup was E. Brown (left end), Freeland (left tackle), Metzger (left guard), Morgan (center), Ross (right guard), Brown (right tackle), Stewart (right end), Morrison (quarterback), K. Morrison (left halfback), Neely (right halfback), Williams (fullback).^[17]

Castle Heights

In the third week of play, the Commodores beat Castle Heights Military Academy 14–0. The contest was billed as practice for the upcoming game with Tennessee.^[18] The low score was a bit of a let down.^[18]

Tennessee

Vanderbilt then won a tough match 18–0 over the Tennessee Volunteers.^[19] After a blocked punt, Vanderbilt's Bo Williams went across for the game's first touchdown.^[19] The second score came when Neely went around right-end for 15 yards and a touchdown.^[19] Neely had another touchdown in the fourth quarter, running 25 yards.^[19] Several fights between players nearly broke out during the game.^[18]

The starting lineup was Anderson (left end), T. Brown (left tackle), Metzger (left guard), Morgan (center), Steagal (right guard), Freeland (right tackle), E. Brown (right end), Robins (quarterback), K. Morrison (left halfback), Neely (right halfback), Williams (fullback).^[19]

Yale

October 22 brought the highlight of the year: a scoreless tie with the defending national champion, coach Ted Coy's Yale Bulldogs.^[21] It was the first time Yale had been held scoreless at home,^[22] and the south's first great showing against an Eastern power.^[23]

The game was played in a pouring rain.^[20] One account reads "Four times brilliant rushes around end by Capt. Neely brought the ball well into Yale territory, only to be lost because of penalties against the visitors. Vanderbilt did not substitute a single player."^[20]

Neely, recalling the game said "The score tells the story a good deal better than I can. All I want to say is that I never saw a football team fight any harder at every point that Vanderbilt fought today – line, ends, and backfield. We went in to give Yale the best we had and I think we about did it."^[24]

The starting lineup was Stewart (left end), Freeland (left tackle), F. Brown (left guard), Morgan (center), Metzger (right guard), Noel (right tackle), E. Brown (right end), R. Morrison (quarterback), Neely (left halfback), . Morrison (right halfback), Williams (fullback).^[20]

Mississippi

Vanderbilt won a close game over Mississippi 9–2. Late in the first quarter, Ray Morrison ran 90 yards for Vanderbilt's touchdown on a punt return.^[26] On the ensuing drive, Neely set up to punt, and the ball got away from him. Attempting to recover it, he booted the ball behind his own goal line, netting a safety for Mississippi.^[26] Neely later made a 22-yard field goal.^[25] John Heisman was field judge, and McGugin did not want to show too much, playing Heisman's Georgia Tech in two weeks.^[27]

The starting lineup was Stewart (left end), T. Brown (left tackle), Brown (left guard), Morgan (center), Metzger (right guard), Freeland (right tackle), E. Brown (right end), Morrison (quarterback), Neely (left halfback), K. Morrison (right halfback), Williams (fullback).^[26]

Louisiana State

The Commodores overwhelmed the Louisiana State Tigers 22–0. Vanderbilt's first score came on a 12-yard Kent Morrison run. He also scored the second touchdown. Neely made the third score, and the last was from an Enoch Brown run of 60 yards.^[28] Subs were sent in by game's end.^[27]

The starting lineup was Stewart (left end), T. Brown (left tackle), Brown (left guard), Morgan (center), Metzger (right guard), Freeland (right tackle), E. Brown (right end), Morrison (quarterback), Neely (left halfback), K. Morrison (right halfback), Martin (fullback).^[28]

Georgia Tech

Vanderbilt beat Heisman's Georgia Tech 22–0.^[29] Sewanee's coach Harris Cope was at the game, and again McGugin took to conventional football, resulting in a scoreless first half.^[27]

The first score came on a pass from Bill Neely to Enoch Brown. Two minutes later, Ray Morrison got away for another touchdown, and the game opened up from there.^[30] Morrison was considered the game's star.^[29] After an illegal forward pass, Vanderbilt had another touchdown (Bradley Walker's officiating drew criticism throughout).^[29] The last score came after a 25-yard run from Neely and was scored by a dodging Morrison.^[29]

The starting lineup was Stewart (left end), Freeland (left tackle), Metzger (left guard), Morgan (center), Stegall (right guard), T. Brown (right tackle), E. Brown (right end), Morrison (quarterback), K. Morrison (left halfback), Neely (right halfback), Williams (fullback).^[29]

Sewanee

The Commodores defeated the Sewanee Tigers 23–6. By the second quarter, Sewanee's defense was "completely dismantled" by Vanderbilt's rushing attack.^[31] Sewanee had one first down all game – an 85-yard run by Aubrey Lanier.^[31]

The starting lineup was Stewart (left end), T. Brown (left tackle), Stegall (left guard), Morgan (center), Metzger (right guard), Freeland (right tackle), E. Brown (right end), Morrison (quarterback), K. Morrison (left halfback), Neely (right halfback), Williams (fullback).^[31]

Legacy

Both Metzger and Morrison were selected for an Associated Press Southeast Area All-Time football team 1869–1919 era.^[34]

Depth chart

The following chart provides a visual depiction of Vanderbilt's lineup during the 1910 season with games started at the position reflected in parentheses. The chart mimics a short punt formation while on offense, with the quarterback under center.