CCDC82

CCDC82

CCDC82

Protein found in humans

Coiled-Coil Domain Containing protein 82 (CCDC82) is a protein that in humans, is encoded for by the gene of the same name, CCDC82. The CCDC82 gene is expressed in nearly all of human tissues at somewhat low rates. As of today, there are no patents involving CCDC82 and the function remains unknown.

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Gene

CCDC82 is located on chromosome 11 at 11q21.5.[5] It contains two domains of unknown function, DUF4196 and DUF4211.[6] The DNA sequence is 37,155 base pairs long[7] and contains 7 exons.[8]

Homology

CCDC82 is present in many orthologs. It is conserved throughout other mammals, reptiles, birds and bony fish. It is not found in invertebrates, bacteria or fungi. There are no paralogs.[9]

Unrooted phylogenetic tree
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mRNA

Promoter

The predicted promoter for CCDC82 is located on the minus strand and spans from base pairs 96,122,963 to 96,123,587. It is 625 base pairs long.[10]

Transcription factors

The transcription factors listed below are for the predicted promoter sequence and are located on the minus strand.[11]

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Protein

The protein it encodes for is 344 amino acids in length. The protein itself is very acidic and is very rich in aspartic acid and glutamic acid. It is also very deficient in alanine, containing only two alanines in the entire sequence. The alanines are located adjacent to each other, amino acid number 233 and 234. Alanine 233 is highly conserved throughout the orthologs. The molecular weight is 40.0 kdal and the isoelectric point is 4.383[12]

Expression

This image shows the level of expression of CCDC82 in different tissues throughout the body.

CCDC82 is found in nearly all tissues in the human body, however it is present in higher quantities in the skeletal muscles, adrenal cortex, and the trigeminal ganglion.[13][14]

Post translational modifications

CCDC82 has several predicted phosphorylation sites.[15] There are 32 predicted serine phosphorylation sites, 5 threonine, and 3 tyrosine.[16]

Interactions

CCDC82 is known to interact with two proteins. It indirectly interacts with VHL, a gene that encodes for a tumor suppressor and ubiquitin protein ligase. It also interacts with EWSR1, which functions as a transcriptional repressor.[17]

Clinical significance

CCDC82 is a circulat-responsive gene.[18] Circulat is a product designed to restore systemic vascular health. It is a plant based product and taken by patients who suffer from diabetes or circulatory problems.[19]

Possible function

Based on the information that CCDC82 is affected by the Circulat product it could be hypothesized that CCDC82 is involved in circulatory function. However, this is purely speculation.

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000149231 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000079084 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "CCDC82 Genomic Views". GeneCards. Weizmann Institute of Science.
  6. [6]
    "CCDC82 Protein Domains and Families". GeneCards. Weizmann Institute of Science.
  7. [7]
    "Homo sapiens chromosome 11, GRCh37.p10 Primary Assembly". NCBI. 13 August 2013.
  8. [8]
    "Prediction of several variants of multiple genes". Softberry.
  9. [9]
    "CCDC82 BLAST". BLAST. NCBI.
  10. [10]
    "Genome Browser". ElDorado. Genomatix.
  11. [11]
    "Transcription Factor Binding Sites". ElDorado. Genomatix.
  12. [12]
    "SAPS". Biology Workbench. SDSU.[permanent dead link]
  13. [13]
    "Large-scale analysis of the human transcriptome (HG-U133A)". GeoProfiles. NCBI.
  14. [14]
    Hu RM, Han ZG, Song HD, Peng YD, Huang QH, Ren SX, Gu YJ, Huang CH, Li YB, Jiang CL, Fu G, Zhang QH, Gu BW, Dai M, Mao YF, Gao GF, Rong R, Ye M, Zhou J, Xu SH, Gu J, Shi JX, Jin WR, Zhang CK, Wu TM, Huang GY, Chen Z, Chen MD, Chen JL (August 2000). "Gene expression profiling in the human hypothalamus-pituitary-adrenal axis and full-length cDNA cloning". Proc. Natl. Acad. Sci. U.S.A. 97 (17): 9543–8. Bibcode:2000PNAS...97.9543H. doi:10.1073/pnas.160270997. PMC 16901. PMID 10931946.
  15. [15]
    Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M (November 2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks". Cell. 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983. S2CID 7827573.
  16. [16]
    "CCDC82". NetPhos 2.0. Center for Biological Analysis. Archived from the original on 2013-10-16. Retrieved 2013-05-14.
  17. [17]
    "CCDC82". Gene Cards. Weizmann Institute of Science. Retrieved 2 May 2013.
  18. [18]
    Antoshechkin A, Olalde J, Magarici M, Muhammad A, Salom A, Suarez J, Amendola F (August 2007). "Analysis of effects of the herbal preparation Circulat on gene expression levels in cultured human fibroblasts". Phytother Res. 21 (8): 777–89. doi:10.1002/ptr.2174. PMID 17514633. S2CID 29862628.
  19. [19]
    "About Circulat". Circulat. Circulat Biotech LLC. Archived from the original on 2013-08-31.
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This article uses material from the Wikipedia article CCDC82, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.