CLCA1
CLCA1
Protein-coding gene in the species Homo sapiens
Chloride channel accessory 1 is a protein that in humans is encoded by the CLCA1 gene.[5][6]
Quick Facts Identifiers, Aliases ...
| CLCA1 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | CLCA1, CACC, CACC1, CLCRG1, CaCC-1, GOB5, hhCaCC-1, chloride channel accessory 1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 603906 MGI: 1346342 HomoloGene: 984 GeneCards: CLCA1 | ||||||||||||||||||||||||||||||||||||||||||||||||||
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This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.[6] Protein structure prediction methods suggest the N-terminal region of CLCA1 protein is a zinc metalloprotease.[7]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Gruber AD, Elble RC, Ji HL, Schreur KD, Fuller CM, Pauli BU (Jan 1999). "Genomic cloning, molecular characterization, and functional analysis of human CLCA1, the first human member of the family of Ca2+-activated Cl− channel proteins". Genomics. 54 (2): 200–14. doi:10.1006/geno.1998.5562. PMID 9828122.
- Hume JR, Duan D, Collier ML, et al. (2000). "Anion transport in heart". Physiol. Rev. 80 (1): 31–81. doi:10.1152/physrev.2000.80.1.31. PMID 10617765. S2CID 15954128.
- Pauli BU, Abdel-Ghany M, Cheng HC, et al. (2001). "Molecular characteristics and functional diversity of CLCA family members". Clin. Exp. Pharmacol. Physiol. 27 (11): 901–5. doi:10.1046/j.1440-1681.2000.03358.x. PMID 11071307. S2CID 28762005.
- Agnel M, Vermat T, Culouscou JM (1999). "Identification of three novel members of the calcium-dependent chloride channel (CaCC) family predominantly expressed in the digestive tract and trachea". FEBS Lett. 455 (3): 295–301. doi:10.1016/S0014-5793(99)00891-1. PMID 10437792. S2CID 82094058.
- Dias Neto E, Correa RG, Verjovski-Almeida S, et al. (2000). "Shotgun sequencing of the human transcriptome with ORF expressed sequence tags". Proc. Natl. Acad. Sci. U.S.A. 97 (7): 3491–6. Bibcode:2000PNAS...97.3491D. doi:10.1073/pnas.97.7.3491. PMC 16267. PMID 10737800.
- Liu QH, Williams DA, McManus C, et al. (2000). "HIV-1 gp120 and chemokines activate ion channels in primary macrophages through CCR5 and CXCR4 stimulation". Proc. Natl. Acad. Sci. U.S.A. 97 (9): 4832–7. Bibcode:2000PNAS...97.4832L. doi:10.1073/pnas.090521697. PMC 18318. PMID 10758170.
- Toda M, Tulic MK, Levitt RC, Hamid Q (2002). "A calcium-activated chloride channel (HCLCA1) is strongly related to IL-9 expression and mucus production in bronchial epithelium of patients with asthma". J. Allergy Clin. Immunol. 109 (2): 246–50. doi:10.1067/mai.2002.121555. PMID 11842292.
- Greenwood IA, Miller LJ, Ohya S, Horowitz B (2002). "The large conductance potassium channel beta-subunit can interact with and modulate the functional properties of a calcium-activated chloride channel, CLCA1". J. Biol. Chem. 277 (25): 22119–22. doi:10.1074/jbc.C200215200. PMID 11994272.
- Abdel-Ghany M, Cheng HC, Elble RC, Pauli BU (2002). "Focal adhesion kinase activated by beta(4) integrin ligation to mCLCA1 mediates early metastatic growth". J. Biol. Chem. 277 (37): 34391–400. doi:10.1074/jbc.M205307200. PMID 12110680.
- Loewen ME, Bekar LK, Gabriel SE, et al. (2002). "pCLCA1 becomes a cAMP-dependent chloride conductance mediator in Caco-2 cells". Biochem. Biophys. Res. Commun. 298 (4): 531–6. doi:10.1016/S0006-291X(02)02498-1. PMID 12408984.
- Zhou Y, Shapiro M, Dong Q, et al. (2003). "A calcium-activated chloride channel blocker inhibits goblet cell metaplasia and mucus overproduction". Mucus Hypersecretion in Respiratory Disease. Novartis Foundation Symposia. Vol. 248. pp. 150–65, discussion 165–70, 277–82. doi:10.1002/0470860790.ch10. ISBN 9780470844786. PMID 12568493.
- Abdel-Ghany M, Cheng HC, Elble RC, et al. (2004). "The interacting binding domains of the beta(4) integrin and calcium-activated chloride channels (CLCAs) in metastasis". J. Biol. Chem. 278 (49): 49406–16. doi:10.1074/jbc.M309086200. PMID 14512419.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
- Hegab AE, Sakamoto T, Uchida Y, et al. (2004). "CLCA1 gene polymorphisms in chronic obstructive pulmonary disease". J. Med. Genet. 41 (3): 27e–27. doi:10.1136/jmg.2003.012484. PMC 1735703. PMID 14985398.
- Kamada F, Suzuki Y, Shao C, et al. (2005). "Association of the hCLCA1 gene with childhood and adult asthma". Genes Immun. 5 (7): 540–7. doi:10.1038/sj.gene.6364124. PMID 15318163.
- Ritzka M, Stanke F, Jansen S, et al. (2005). "The CLCA gene locus as a modulator of the gastrointestinal basic defect in cystic fibrosis". Hum. Genet. 115 (6): 483–91. doi:10.1007/s00439-004-1190-y. PMID 15490240. S2CID 12935280.
- Gibson A, Lewis AP, Affleck K, et al. (2005). "hCLCA1 and mCLCA3 are secreted non-integral membrane proteins and therefore are not ion channels". J. Biol. Chem. 280 (29): 27205–12. doi:10.1074/jbc.M504654200. PMID 15919655.
- Jeong SM, Park HK, Yoon IS, et al. (2005). "Cloning and expression of Ca2+-activated chloride channel from rat brain". Biochem. Biophys. Res. Commun. 334 (2): 569–76. doi:10.1016/j.bbrc.2005.06.122. PMID 16023076.
- CLCA1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Human CLCA1 genome location and CLCA1 gene details page in the UCSC Genome Browser.
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