Dimethylallyltranstransferase
Dimethylallyltranstransferase
Mammalian protein found in Homo sapiens
Dimethylallyltranstransferase (DMATT), also known as farnesylpyrophosphate synthase (FPPS) or as farnesyldiphosphate synthase (FDPS), is an enzyme that in humans is encoded by the FDPS gene and catalyzes the transformation of dimethylallylpyrophosphate (DMAPP) and isopentenyl pyrophosphate (IPP) into farnesylpyrophosphate (FPP).[5][6]
Quick Facts FDPS, Available structures ...
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Quick Facts Identifiers, EC no. ...
Dimethylallyltranstransferase | |||||||||
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Identifiers | |||||||||
EC no. | 2.5.1.1 | ||||||||
CAS no. | 9032-79-5 | ||||||||
Databases | |||||||||
IntEnz | IntEnz view | ||||||||
BRENDA | BRENDA entry | ||||||||
ExPASy | NiceZyme view | ||||||||
KEGG | KEGG entry | ||||||||
MetaCyc | metabolic pathway | ||||||||
PRIAM | profile | ||||||||
PDB structures | RCSB PDB PDBe PDBsum | ||||||||
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Quick Facts Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase), Identifiers ...
Farnesyldiphosphate synthase (farnesylpyrophosphate synthetase, dimethylallyltranstransferase, geranyltranstransferase) | |||||||
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Identifiers | |||||||
Symbol | FDPS | ||||||
NCBI gene | 2224 | ||||||
HGNC | 3631 | ||||||
OMIM | 134629 | ||||||
RefSeq | NM_002004 | ||||||
UniProt | P14324 | ||||||
Other data | |||||||
EC number | 2.5.1.1 | ||||||
Locus | Chr. 1 q22 | ||||||
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Pyrophosphate is also involved, as both a reactant and a product. Geranylpyrophosphate is created in an intermediate step.
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Banthorpe DV, Bucknall GA, Doonan HJ, Doonan S, Rowan MG (1976). "Biosynthesis of geraniol and nerol in cell-free extracts of Tanacetum vulgare". Phytochemistry. 15 (1): 91–100. Bibcode:1976PChem..15...91B. doi:10.1016/s0031-9422(00)89061-5.
- Sagami H, Ogura K, Seto S, Kurokawa T (November 1978). "A new prenyltransferase from Micrococcus lysodeikticus". Biochemical and Biophysical Research Communications. 85 (2): 572–8. doi:10.1016/0006-291X(78)91201-9. PMID 736921.
- Dimethylallyltranstransferase at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- Overview of all the structural information available in the PDB for UniProt: P14324 (Human Farnesyl pyrophosphate synthaseC) at the PDBe-KB.