FOXO6

FOXO6

FOXO6

Protein-coding gene in the species Homo sapiens

Forkhead box O6 is a protein that in humans is encoded by the FOXO6 gene.[5]

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FoxO6 is expressed in the liver, skeletal muscle, and the hippocampus of the brain.[6] In the liver, FoxO6 normally promotes gluconeogenesis in the fasted state, but insulin blocks Fox06 upon feeding.[6] In a condition of insulin resistance insulin fails to block FoxO6 resulting in continued gluconeogenesis even upon feeding.[6]

References

  1. [1]
    ENSG00000281518 GRCh38: Ensembl release 89: ENSG00000204060, ENSG00000281518 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000052135 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    "Entrez Gene: Forkhead box O6".
  6. [6]
    Lee S, Dong HH (2017). "FoxO integration of insulin signaling with glucose and lipid metabolism". Journal of Endocrinology. 233 (2): R67–R79. doi:10.1530/JOE-17-0002. PMC 5480241. PMID 28213398.

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