IGFBP5

IGFBP5
Available structures
PDB	Ortholog search: PDBe RCSB
List of PDB id codes
	1BOE, 1H59
Identifiers
Aliases	IGFBP5, IBP5, insulin like growth factor binding protein 5
External IDs	OMIM: 146734; MGI: 96440; HomoloGene: 56489; GeneCards: IGFBP5; OMA:IGFBP5 - orthologs
Gene location (Human)
Chr.	Chromosome 2 (human)
End	216,695,549 bp
Gene location (Mouse)
Chr.	Chromosome 1 (mouse)
End	72,914,043 bp
RNA expression pattern
	Top expressed in
	renal medulla; ; urethra; ; saphenous vein; ; nipple; ; vena cava; ; cardia; ; pylorus; ; canal of the cervix; ; left uterine tube; ; right ovary;
	Top expressed in
	ciliary body; ; external carotid artery; ; molar; ; lactiferous gland; ; saccule; ; extraocular muscle; ; ankle; ; otic placode; ; otic vesicle; ; internal carotid artery;
	More reference expression data
	; ; ; ;
	More reference expression data
Gene ontology
Molecular function	fibronectin binding; insulin-like growth factor binding; growth factor binding; insulin-like growth factor I binding; insulin-like growth factor II binding; protein binding;
Cellular component	insulin-like growth factor ternary complex; extracellular region; insulin-like growth factor binding protein complex; endoplasmic reticulum lumen; extracellular space;
Biological process	negative regulation of smooth muscle cell proliferation; negative regulation of translation; positive regulation of protein kinase B signaling; intracellular signal transduction; negative regulation of growth; glucose homeostasis; female pregnancy; cellular response to organic cyclic compound; negative regulation of smooth muscle cell migration; negative regulation of osteoblast differentiation; regulation of glucose metabolic process; negative regulation of cell migration; positive regulation of insulin-like growth factor receptor signaling pathway; regulation of cell growth; osteoblast differentiation; response to growth hormone; glucose metabolic process; negative regulation of insulin-like growth factor receptor signaling pathway; hair follicle morphogenesis; regulation of growth; negative regulation of muscle tissue development; striated muscle cell differentiation; lung alveolus development; negative regulation of skeletal muscle hypertrophy; type B pancreatic cell proliferation; cellular response to cAMP; signal transduction; mammary gland involution; human ageing; post-translational protein modification; positive regulation of vascular associated smooth muscle cell proliferation; positive regulation of vascular associated smooth muscle cell migration; regulation of insulin-like growth factor receptor signaling pathway;
	Sources:Amigo / QuickGO
Orthologs
	3488
	16011
	ENSG00000115461
	ENSMUSG00000026185
	P24593
	Q07079
	NM_000599
	NM_010518
	NP_000590
	NP_034648
	Wikidata
View/Edit Human	View/Edit Mouse

IGFBP5

Protein-coding gene in the species Homo sapiens

Insulin-like growth factor-binding protein 5 (IBF-5) is a protein that in humans is encoded by the IGFBP5 gene.^[5] An IGFBP5 gene was recently identified as being important for adaptation to varying water salinity in fish.^[6]

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This article uses material from the Wikipedia article IGFBP5, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000115461 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000026185 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid7511611-5] [5]
Allander SV, Larsson C, Ehrenborg E, Suwanichkul A, Weber G, Morris SL, Bajalica S, Kiefer MC, Luthman H, Powell DR (May 1994). "Characterization of the chromosomal gene and promoter for human insulin-like growth factor binding protein-5". J Biol Chem. 269 (14): 10891–8. doi:10.1016/S0021-9258(17)34142-X. PMID 7511611.

[pmid27706866-6] [6]
Kusakabe M, Ishikawa A, Ravinet M, Yoshida K, Makino T, Toyoda A, Fujiyama A, Kitano J (2017). "Genetic basis for variation in salinity tolerance between stickleback ecotypes". Molecular Ecology. 26 (1): 304–319. Bibcode:2017MolEc..26..304K. doi:10.1111/mec.13875. PMID 27706866. S2CID 7821799.

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[1]

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[3]

[4]

IGFBP5

IGFBP5

References

Further reading

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