Integrin_alpha-1
Integrin alpha-1
Mammalian protein found in Homo sapiens
Integrin alpha-1 also CD49a is an integrin alpha subunit encoded in humans by the gene ITGA1. It makes up half of the α1β1 integrin duplex. Though CD49a can bind a number of ligands including collagen IV, collagen I, and others.[5]
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CD49a has been implicated as a marker of tissue resident memory T cells, where it may be coexpressed with other markers CD103 and CD69.[6] It has been shown to affect the motility of T cells.[7]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
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- Reilly EC, Sportiello M, Emo KL, Amitrano AM, Jha R, Kumar AB, Laniewski NG, Yang H, Kim M, Topham DJ (9 September 2021). "CD49a Identifies Polyfunctional Memory CD8 T Cell Subsets that Persist in the Lungs After Influenza Infection". Frontiers in Immunology. 12: 728669. doi:10.3389/fimmu.2021.728669. PMC 8462271. PMID 34566986.
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- Plenz GA, Deng MC, Robenek H, Völker W (2003). "Vascular collagens: spotlight on the role of type VIII collagen in atherogenesis". Atherosclerosis. 166 (1): 1–11. doi:10.1016/S0021-9150(01)00766-3. PMID 12482545.
- Clover J, Dodds RA, Gowen M (1992). "Integrin subunit expression by human osteoblasts and osteoclasts in situ and in culture". J. Cell Sci. 103 (1): 267–71. doi:10.1242/jcs.103.1.267. PMID 1429908.
- Bodary SC, McLean JW (1990). "The integrin beta 1 subunit associates with the vitronectin receptor alpha v subunit to form a novel vitronectin receptor in a human embryonic kidney cell line". J. Biol. Chem. 265 (11): 5938–41. doi:10.1016/S0021-9258(19)39269-5. PMID 1690718.
- Sonnenberg A, Linders CJ, Modderman PW, et al. (1990). "Integrin recognition of different cell-binding fragments of laminin (P1, E3, E8) and evidence that alpha 6 beta 1 but not alpha 6 beta 4 functions as a major receptor for fragment E8". J. Cell Biol. 110 (6): 2145–55. doi:10.1083/jcb.110.6.2145. PMC 2116116. PMID 1693624.
- Belkin VM, Belkin AM, Dol'nikova AE, et al. (1992). "[Isolation and characteristics of ligand specificity of VLA-1 integrin from human smooth muscles]". Biokhimiia. 56 (12): 2198–206. PMID 1807406.
- Bank I, Roth D, Book M, et al. (1991). "Expression and functions of very late antigen 1 in inflammatory joint diseases". J. Clin. Immunol. 11 (1): 29–38. doi:10.1007/BF00918792. PMID 1827128. S2CID 6198792.
- Tabibzadeh S (1990). "Evidence of T-cell activation and potential cytokine action in human endometrium". J. Clin. Endocrinol. Metab. 71 (3): 645–9. doi:10.1210/jcem-71-3-645. PMID 2144294.
- Tawil NJ, Houde M, Blacher R, et al. (1990). "Alpha 1 beta 1 integrin heterodimer functions as a dual laminin/collagen receptor in neural cells". Biochemistry. 29 (27): 6540–4. doi:10.1021/bi00479a028. PMC 2710132. PMID 2169872.
- Belkin VM, Belkin AM, Koteliansky VE (1990). "Human smooth muscle VLA-1 integrin: purification, substrate specificity, localization in aorta, and expression during development". J. Cell Biol. 111 (5 Pt 1): 2159–70. doi:10.1083/jcb.111.5.2159. PMC 2116325. PMID 2229189.
- MacDonald TT, Horton MA, Choy MY, Richman PI (1990). "Increased expression of laminin/collagen receptor (VLA-1) on epithelium of inflamed human intestine". J. Clin. Pathol. 43 (4): 313–5. doi:10.1136/jcp.43.4.313. PMC 502365. PMID 2341567.
- Takada Y, Strominger JL, Hemler ME (1987). "The very late antigen family of heterodimers is part of a superfamily of molecules involved in adhesion and embryogenesis". Proc. Natl. Acad. Sci. U.S.A. 84 (10): 3239–43. Bibcode:1987PNAS...84.3239T. doi:10.1073/pnas.84.10.3239. PMC 304844. PMID 3033641.
- Hemler ME, Huang C, Schwarz L (1987). "The VLA protein family. Characterization of five distinct cell surface heterodimers each with a common 130,000 molecular weight beta subunit". J. Biol. Chem. 262 (7): 3300–9. doi:10.1016/S0021-9258(18)61504-2. PMID 3546305.
- Kono Y, Yang S, Letarte M, Roberts EA (1996). "Establishment of a human hepatocyte line derived from primary culture in a collagen gel sandwich culture system". Exp. Cell Res. 221 (2): 478–85. doi:10.1006/excr.1995.1399. PMID 7493648.
- Eglinton BA, Roberton DM, Cummins AG (1995). "Phenotype of T cells, their soluble receptor levels, and cytokine profile of human breast milk". Immunol. Cell Biol. 72 (4): 306–13. doi:10.1038/icb.1994.46. PMID 7806264. S2CID 25016970.
- Salter DM, Godolphin JL, Gourlay MS (1995). "Chondrocyte heterogeneity: immunohistologically defined variation of integrin expression at different sites in human fetal knees". J. Histochem. Cytochem. 43 (4): 447–57. doi:10.1177/43.4.7897185. PMID 7897185.
- Pfaff M, Aumailley M, Specks U, et al. (1993). "Integrin and Arg-Gly-Asp dependence of cell adhesion to the native and unfolded triple helix of collagen type VI". Exp. Cell Res. 206 (1): 167–76. doi:10.1006/excr.1993.1134. PMID 8387021.
- Briesewitz R, Epstein MR, Marcantonio EE (1993). "Expression of native and truncated forms of the human integrin alpha 1 subunit". J. Biol. Chem. 268 (4): 2989–96. doi:10.1016/S0021-9258(18)53871-0. PMID 8428973.
- Langholz O, Röckel D, Mauch C, et al. (1996). "Collagen and collagenase gene expression in three-dimensional collagen lattices are differentially regulated by alpha 1 beta 1 and alpha 2 beta 1 integrins". J. Cell Biol. 131 (6 Pt 2): 1903–15. doi:10.1083/jcb.131.6.1903. PMC 2120685. PMID 8557756.
- Gardner H, Kreidberg J, Koteliansky V, Jaenisch R (1996). "Deletion of Integrin Alpha1 by Homologous Recombination Permits Normal Murine Development But Gives Rise to a Specific Deficit in Cell Adhesion". Dev.Biol. 175 (2): 301–313. doi:10.1006/dbio.1996.0116. PMID 8626034.
- CD49a+antigen at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
- ITGA1 Info with links in the Cell Migration Gateway Archived 2014-12-11 at the Wayback Machine
- Human ITGA1 genome location and ITGA1 gene details page in the UCSC Genome Browser.
- PDBe-KB provides an overview of all the structure information available in the PDB for Human Integrin alpha-1
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