KMO_(gene)

KMO (gene)

KMO (gene)

Protein-coding gene in the species Homo sapiens

Kynurenine 3-monooxygenase is an enzyme that in humans is encoded by the KMO gene.[5][6]

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Kynurenine 3-monooxygenase (KMO; EC 1.14.13.9) is an NADPH-dependent flavin monooxygenase that catalyzes the hydroxylation of the L-tryptophan metabolite L-kynurenine to form L-3-hydroxykynurenine.[supplied by OMIM][6] This is the first step in the degradation of Kyneurinine to Quinolinic acid. This pathway is involved in the activation of cytokine mediated changes in behavior due to inflammatory stimuli such as infections.[7] The KMO gene is upregulated in the lung parenchyma of smokers. [8]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000117009 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000039783 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Alberati-Giani D, Cesura AM, Broger C, Warren WD, Rover S, Malherbe P (Sep 1997). "Cloning and functional expression of human kynurenine 3-monooxygenase". FEBS Lett. 410 (2–3): 407–12. doi:10.1016/S0014-5793(97)00627-3. PMID 9237672. S2CID 26490151.
  6. [6]
    "Entrez Gene: KMO kynurenine 3-monooxygenase (kynurenine 3-hydroxylase)".
  7. [7]
    Dantzer R, O'Connor JC, Lawson MA, Kelley KW (2011), "Inflammation-associated Depression: From Serotonin to Kyneurenine", Psychoneuroendocrinology, 36 (3): 426–36, doi:10.1016/j.psyneuen.2010.09.012, PMC 3053088, PMID 21041030
  8. [8]
    Pintarelli G, Noci S, Maspero D, Pettinicchio A, Dugo M, De Cecco L, Incarbone M, Tosi D, Santambrogio L, Dragani TA, Colombo F (September 2019). "Cigarette smoke alters the transcriptome of non-involved lung tissue in lung adenocarcinoma patients". Scientific Reports. 9 (1): 13039. Bibcode:2019NatSR...913039P. doi:10.1038/s41598-019-49648-2. PMC 6736939. PMID 31506599.

Further reading


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