Latrophilin

Latrophilin

Latrophilin

G-protein coupled receptor

Latrophilins are a group of highly conserved G-protein coupled receptors from the adhesion G protein-coupled receptor family. These receptors were originally identified based on their ability to bind to a component of black widow spider venom known as alpha-latrotoxin.[1] This conserved family of membrane proteins has up to three homologues in chordate species, including humans.[2]

Quick Facts Identifiers, Symbol ...
Quick Facts EGF, latrophilin and seven transmembrane domain containing 1, Identifiers ...
Quick Facts Identifiers, Symbol ...
Quick Facts Identifiers, Symbol ...
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The precise functions of latrophilins remain unknown.[2] Genetic defects in latrophilin genes have been associated with diseases such as attention-deficit hyperactivity disorder and cancer.[3]

Human proteins containing this domain

See also

References

  1. [1]
    Kreienkamp HJ, Soltau M, Richter D, Böckers T (2002). "Interaction of G-protein-coupled receptors with synaptic scaffolding proteins". Biochem. Soc. Trans. 30 (4): 464–8. doi:10.1042/BST0300464. PMID 12196116.
  2. [2]
    Silva, JP; Ushkaryov, YA (2010). "The Latrophilins, "Split-Personality" Receptors". Adhesion-GPCRS. Advances in Experimental Medicine and Biology. Vol. 706. pp. 59–75. doi:10.1007/978-1-4419-7913-1_5. ISBN 978-1-4419-7912-4. PMC 3145135. PMID 21618826.
  3. [3]
    Meza-Aguilar, Diana G; Boucard, Antony A (1 January 2014). "Latrophilins updated". Biomolecular Concepts. 5 (6): 457–478. doi:10.1515/bmc-2014-0032. PMID 25429599. S2CID 207442054.
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