When Cat breaks up with Glenn, Lola decides to be supportive and break up with her own boyfriend, Owen, by telling him that she has brain cancer.

Things get tense after Cat sneezed on Lola. Meanwhile, Briggs tries to get Owen back on the police force.

The Chief calls a staff meeting to discuss Lola's nonexistent brain tumor.

The Chief tries to help a boy who has aged rapidly. Meanwhile, Blake tries to help people via the healing power of laughter.

Another doctor tries to use Blake's method: the healing power of laughter.

In this very special episode, things are told from the perspective of a visiting doctor from Puerto Rico.

Glen gets upset about Cat's new boyfriend. Meanwhile, a new doctor may be able to cure The Chief.

Blake challenges Nate to a competition where the two doctors must perform surgery using only the healing power of laughter.

Blake tells Lola he knows her brain tumor is fake and asks to use "the healing power of laughter" to cure it, in order to upset his rival clown Dr. Nate Schachter. Meanwhile, Glen tries to get revenge on Cat's new boyfriend, six-year-old boy Little Nicky, by giving him a vasectomy. Dr. Max Von Sydow offers to cure The Chief.

In the season finale Max performs surgery on The Chief, after which she resembles Eva Longoria. Blake tries to cure Lola's nonexistent tumor with "the healing power of laughter," accidentally killing her in the process. Blake announces his plans to start his own private practice in a spin-off called, Dr. Blake Downs, M.D. At the funeral, Lola is revealed to have faked her death and attended in disguise.

Webisodes 1 and 2. Faux commercial for the "Epic 12 Hour Season Finale Event" of TV series NTSF:SD:SUV:: (National Terrorism Strike Force: San Diego: Sports Utility Vehicle). In the post-show message from Rob Corddry, Corddry reminisces about plays he used to put on for his male babysitter.

Guest stars: Nate Corddry, Ed Helms, Dannah Feinglass (Webisode 1)
Michael Cera (voice only), Nick Offerman (Webisode 2)

Webisodes 3 and 4. Faux commercial for anti-depressant berry drink, Nutricai, endorsed by Chris Elliott. In the post show-message, Corddry reads an excerpt from the #1 National Best Seller, Hospital of Children by Ryan Berg, upon which the series was based.

Guest stars: Nate Corddry, Ed Helms, Nick Offerman (Webisode 3)
Nick Kroll, Zandy Hartig (Webisode 4)

Webisodes 5 and 6. Faux commercial for the "Epic 12 Hour Season Finale Event" of TV series NTSF:SD:SUV (National Terrorism Strike Force: San Diego: Sports Utility Vehicle). In the post show-message, Corddry is with "the real Dr. Blake Downs" and "the real Cutter Spindell" (who is actually David Wain).

Guest stars: Nick Offerman, Jason Sudeikis, Seth Morris, Jamie Denbo, Brian Huskey (Webisode 5)
Michael Cera (voice only), David Wain, Joe Lo Truglio (voice only), Cutter Garcia (Webisode 6)

Webisodes 7 and 8. Faux commercial for the "Epic 12 Hour Season Finale Event" of TV series NTSF:SD:SUV (National Terrorism Strike Force: San Diego: Sports Utility Vehicle). In the post-show message from Rob Corddry shares where the idea for Childrens Hospital came from.

Guest stars: Ed Helms, Nate Corddry, Nick Kroll, Zandy Hartig, Jason Sudeikis, Seth Morris, Jamie Denbo, A.D. Miles, John Ross Bowie (Webisode 7)
Michael Cera (voice only), Nick Kroll, Seth Morris, A.D. Miles, John Ross Bowie (Webisode 8)

Webisodes 9 and 10. Faux commercial for the "Epic 12 Hour Season Finale Event" of TV series NTSF:SD:SUV (National Terrorism Strike Force: San Diego: Sports Utility Vehicle). In the post-show message from Rob Corddry plays some clips of his favorite moments from the web series, which all feature only him.

Guest stars: Nick Offerman, Nick Kroll, Zandy Hartig, Seth Morris, Jamie Denbo, John Ross Bowie (Webisode 9)
Michael Cera (voice only), Eva Longoria, Ed Helms, Nate Corddry, John Ross Bowie, Nick Offerman (Webisode 10)

Cat struggles to get over Lola's death. Sy Mittleman, the new administrator arrives, and the entire staff instantly hates him, except for The Chief who is in love with him. Glenn discovers the cure for cancer is butterfly semen. Blake Downs is given his own spin-off, Blake Downs, M.D., which is promptly canceled, causing him to decide to return to Childrens Hospital.

Cat goes into labor with Little Nicky's baby. Little Nicky's advanced aging disease causes him to take on the tendencies of an old man as the disease begins to kill him. Lola Spratt returns from the hospital to explain that she faked her death, but everyone believes she is a ghost. Blake Downs returns to the hospital, following the failure of his private practice/spin-off. New doctor Valerie Flame takes over narrating duties on the show for Cat Black when complications occur in the birth of she and Nicky's child.

Dr. Maestro asks Dr. Flame to stop his heart so that he can find Dr. Spratt in the spirit world. A creepy EMT wants to show The Chief his "sexy costume."

Dr. Blake's clown brother comes to visit and borrows money from Dr. Blake to pay off his gambling debts, while telling him it's for an operation. A mascot from a local theme park starts suspiciously, repeatedly bringing in children with broken arms for treatment. The hospital is turned into a youth hostel, and Sy gets conned by an attractive young foreign girl.

The staff must choose between saving an old black man and a young white kid. Insult comic Jeffrey Ross brings his child into the O.R., but the staff is more concerned with enjoying his humor than treating his child. Two Star Trek nerds dressed in uniforms (one as a Klingon) visit the hospital.

An episode of TV news magazine News Readers covering the filming of the final episode of Childrens Hospital, complete with behind the scenes looks at the show. Cutter Spindell (who portrays Blake Downs on the show within the show) interferes to save the series, convincing protesters that they're saving an actual children's hospital.

Ben Hayflick (Kurtwood Smith) from the National Division of Health shows up to intimidate Dr. Richie into keeping his cancer cure a secret. One of Valerie's patients is a young psychic girl (Laura Marano) and the staff uses her to get insurance info from a comatose patient. Dr. Maestro treats a child with a knife in his chest, refusing to believe that the knife is causing the kid's medical problems.

In a parody of Do the Right Thing, a heat wave plagues the hospital leading to violence and several steamy sexual encounters.

Dr. Richie and Rabbi Jewy McJew Jew (David Wain) compete for Dr. Flame's affections. Briggs, Dr. Maestro's old police partner, pays the hospital a visit and Maestro checks his prostate while the two reminisce about a drug bust. Facing a budget crisis, Sy tries to decide between getting rid of the coffee machine or firing one of the doctors.

It's Take Your Daughter to Work Day at the hospital and the staff all bring in their children. The Chief brings her 27-year-old daughter (Lizzy Caplan) who she keeps treating like a child. Blake Downs brings his five clown-faced daughters whose singing group he coaches. Dr. Richie's daughter discovers a child patient whose plug has fallen out, but she must wait to re-plug him until after sundown since it is Sabbath and she cannot perform any work. Drs. Flame and Maestro try to convince a hermaphrodite which gender to choose, with each doctor vying for their own gender.

Dr. Spratt is asked by a right-wing, pro-life Senator (Ed Begley Jr.) to abort his sixteen-year-old son. Dr. Maestro struggles with a ten-year-old kid who keeps beating him up.

In this (fake) live episode, the Childrens Hospital doctors must reattach a sultan's finger to his hand. Since the sultan doesn't want to be treated by Jews or clowns, Blake must decide to remove his clown makeup. However, the sultan's finger goes missing, until it is revealed to be with the Chief because she wanted to use the "royal DNA" in it to be with one of the sultan's assistants. Revelations about Cat Black and Valerie Flame are also revealed. Most of this happens as two of the three cameras used to film this episode "live" crash into each other and break, forcing the crew to use only one camera.

The Childrens Hospital Crew is called in on a Saturday to rescue a child sinking in quicksand, but Dr. Lola Spratt's return is delayed.

Detective Chance Briggs (Nick Offerman) turns up looking for access to Ward 8, ward of criminally insane children, from Dr. Owen Maestro. Dr. Blake Downs returns to his roots in order to help his old girlfriend Britches (Sarah Silverman). Dr. Glenn Richie, now injured after catching his hand in his own car door, has a fling with The Chief.

Dr. Blake Downs' new landlord kicks him out for being a clown, so he needs a place to stay. Meanwhile, Dr. Brian (Jordan Peele) returns to Childrens Hospital after leaving his job as a consultant on the medical drama "Black Hospital." Also, Dr. Valerie Flame is attracted to a naked Dr. Cat Black.

When the group realizes space is limited in their apartment, they resort to having to kick someone out, and Glenn and Lola want to tell the group about their relationship. Meanwhile, Sy has been forced to live in an out-of-order restroom at the hospital. In the end, Glenn and Lola announce their relationship, and decide to move into a room together, solving the space problem in the apartment, while Sy is left hanging after almost getting to stay with the group.

A new plastic surgeon named Tugg makes Owen and Glenn jealous and eager to get rid of him, until he could possibly solve a mix-up in the maternity ward (where parents are getting the wrong babies). Eventually, Tugg has to leave after taking the blame for the mix-up. Meanwhile, Blake confronts Valerie about her raping of him the previous year, but she just puts him down.

It's the "Lost Episode" from 1976. Glenn returns from the Vietnam War to be an abortionist. Lola becomes a female doctor and gets no respect. Americans value their hot dogs. Disco!

Lola and Brian try to reunite Cat with her father. Blake waits for a criminal to be executed so that he can cut out his heart and bring it to the hospital before a minor turns 18, at which point Childrens can no longer treat them. Sy runs a urine drive.

After a beloved doctor passes away, Sy treats all the doctors to therapy sessions and forbids them from doing any work until they're well again. Meanwhile, Blake deals with the controversy of circus clowns versus city clowns, and the Chief struggles with her strange new hearing aid.

Childrens Hospital presents a very special episode that will take you back to simpler times, when ladies wore dresses, men wore top hats and clowns knew their place.

Owen shocks everyone when his secret wife (who doesn't believe he's actually a doctor) brings their injured baby daughter to the hospital for treatment. The Chief is horrified by this news, not least because it may lead to her attending a wedding with Chet the paramedic. And Valerie Flame finds herself playing a very high-stakes chess game against a man who could be the Grim Reaper.

Frustration abounds at the hospital when the doctors are assigned to work the night shift where they learn the ropes from a European doctor that has joined the team, and tragedy strikes at the hospital when a doctor faces death.

The episode focuses on Chet the paramedic and fellow paramedic Shane who gives Chet advice on asking Chief out, even causing Chet to believe he is a woman due to Shane's smooth talking. However, as the episode progresses, Chet begins to question if Shane is real or imaginary after Shane seemingly disappears after giving advice and when things go wrong.

A food poisoning incident at a bar mitzvah brings in a large group of patients, prompting Dr Ritchie to have an adult bar mitzvah to make up for his own being cancelled when he was young. Rabbi McJewjew comes by to help out and re-kindles his affair with Valerie. Owen decides to have his foreskin re-attached when Chief mentions that women prefer it because it's more 'masculine'. When his father tells him he hasn't got his foreskin, Owen tries to fool Chief into attaching a piece of balogna only to be stopped just in time by his father (a tailor) who reveals he was never circumcised—just hemmed. Meanwhile, it's Blake's day off.

After the credits there is a short appearance by the cast of Party Down including Ken Marino and Megan Mullally in character.

It's the second Newsreaders special with Louis LaFonda. In this special, all those sexy actors get their very own spinoff specials.

In this episode, which satirizes Contagion, and whose title satirizes The Girl with the Dragon Tattoo, everyone at Childrens Hospital gets amnesia. After that, it looks as though the only way to get rid of the amnesia is to give the amnesia... amnesia.

Madonna visits the hospital, stunning Owen.

Chief recounts her past, but the doctors aren't interested in her tale.

Sy assigns the staff to organize the patients' records while he is out of the hospital. However, with his absence, the staff consider it as a free day.

While filming an episode of Childrens Hospital, Lynn Williams and Dixie Peters have a romantic rivalry over the director, David Wain, who has divorced the former and married the latter. Meanwhile, Rob Heubel tries to hide his medical condition from the show's crew in order to keep his job with the help of Cutter Spindell.

Owen works with a detective to get to the bottom of strange behavior by kids. A young billionaire doggedly courts an uninterested Lola Spratt.

A look at the British version of "Childrens Hospital".

Guest stars: (For this episode, the following are given star billing in place of the original cast, who are all absent in this episode): Lauren Cohan, Frank Ferrante, Frances Fisher, Sasha Jackson, Dominic Monaghan, Jaime Murray, Jim Piddock, Dileep Rao

A promotion for single moms catches the male doctors' attention.

Sy's spy past comes back to haunt him when his former partner returns to kill him.

The events of a full year at the hospital are chronicled, as Sy struggles to turn the hospital's fortunes around, Owen relentlessly hits on Lola, and the Simon Wiesenthal Center tracks Joseph Mengele.

Guest stars: Beth Dover, Philip Baker Hall, Zandy Hartig, Tina Huang, Kulap Vilaysack

The identity of the mysterious public announcement announcer is finally revealed when Blake and Owen look around the corners of the hospital. Meanwhile, Sy tries to warn Sal Viscuso, the PA announcer, but instead sees the ghost of Arthur Childrens. When Blake finally sees Sal, a young boy who has not died, but rather has just not aged since he was experimented on, he chases after him but is outrun by him. "A friend" tells Blake that he won't be able to catch Sal. All this happens while Chief stays in the door, doing nothing but talking.

Lola has no friends or pets so she gets a law degree and defends Owen, who is charged with murdering a patient by slapping him during surgery.

Sy succumbs to pressure and allows a wounded Mafia kingpin to be admitted. Detective Briggs changes vocations. Chief has a day off.

An episode of Newsreaders takes a look at the death of a cast member.

Blake comes back from the dead. Meanwhile, the hospital staff relocates to a U.S. Army base in Japan.

Blake's son Willy witnesses a murder and it's up to detective Chance Briggs to save the day and also have a lot of sex.

A plane crash interrupts an evening of fun on the base. Owen tangles with a time loop.

Cat and Michael's wedding weekend at a vacation house sees the doctors and their partners entwined in a murder mystery which Owen must solve.

Owen and Dr. Santa Claus have to save a ward full of sick imaginary friends from closure. Cat wants to become a mother.

Lola's spot-on impersonations get her assigned to a government task force as an old love interest complicates matters.

It's Old Fashioned Day at Childrens Hospital. And it lasts longer than a day, which allows for a conflict.

Owen gets a perm, so Chief and Kat have to trick him into one of Chet's immersive Halloween mazes. Glenn's mouse Chilli dies. Blake doesn't understand modern idiomatic expressions.

Sy arranges a wine tasting at the hospital for Valerie and Chief, while Owen poses as Glenn thanks to an unconventional plan. But what will hospital reviewer Levon Bainter think of all this?

Blake is kidnapped, while Owen and Sy struggle to keep Paging Doctor Maestro on the air. Chief is homesick and steals the mail.

Derrick Childrens plots to wrest control of the hospital from Sy. A parody of Shakespeare plays.

Childrens Hospital director David Wain shoots a documentary about his relationship with cast member Just Falcon.

The doctors' stay in Japan comes to a head in a double-episode season finale.

Guest stars: Jack McBrayer, David Wain, Michael Cera

Owen returns to Childrens Hospital after serving a five year prison sentence. He had previously been arrested for betting on his surgeries. Now he's back and ready to redeem himself. Only, to his dismay, Chief forces him to continue betting on surgeries. Realizing the Chief just got her finger sharpened, Owen has to decide between a life of crime and a death by sharp finger.

Master of a thousand faces Lola Spratt must go on a top secret mission involving the President's bastard child. Meanwhile, Owen and Blake make some jokes and break some laws.

A geneticist named Gene analyzes the staff's DNA, revealing that Valerie and Blake are siblings, Chet is going to die, Nurse Dori is a sociopath, and Sy is actually astronaut Neil Armstrong.

The winner of a Childrens Hospital fan fiction contest writes an episode for the series, titled "The Lovers, the Fighters, the Heroes, or: Who Cured the Doctor but the Moon and Blood?", which focuses on Nurse Beth and reveals Owen to be a vampire.

Lola has a superpower: she can pout. Only, when a merciless villain with the power of blindness threatens to use his blinding talents to defeat Lola, it seems all hope is lost. It's pouting versus blindness, and only one superpower can win.

Glenn talks Blake through a romance, a la Cyrano de Bergerac.

The cast of Childrens Hospital appears on a morning talk show to promote crowdfunding for a Childrens Hospital movie.

Sy tries to woo an anonymous blogger. The hospital prepares for a fundraiser headlined by Dean Koontz.

Sy opens a sperm bank. Valerie plans an elaborate heist. Glenn punches a few people. Lola dresses up.

Sy's relationship with his new girlfriend Rhonda is cramping the other doctors' style. Blake and Nurse Dori track down a loose cat.

When a hospital worker is found beheaded, it seems to be a copycat killing of a fifteen-year-old case, which leads to Owen teaming with his old police partner Chance Briggs to find out what's really going on.

Chief enjoys a staycation at the hospital. Blake tries to fit in with Owen's bicycling crew. Glenn is dubbed a rock star surgeon by the media, but worries that his impending 27th birthday will lead to his death.

Glenn has his weekly Shabbat dinner with his family in the Jewish suburbs of São Paulo.

Blake gets revenge on the gang for their relentless pranks.

After being fired, the doctors find new jobs at a crosstown hospital; Blake turns to a life of crime.

When a rare disease appears, the team must journey into the original Childrens Hospital to find the cure; the doctors try to save the hospital's millionth patient.

Nurse Beth's origins in the Childrens Hospital basement, where she must navigate the social hierarchy of the nurses.

A variety show from the 1950s, The Show You Watch, is revered for its weekly visit to Childrens Hospital.

Blake, Lola and Glenn are excited to attend the Doctor of the Year Convention in Las Vegas; Owen visits his mother.

Dr. Cat Black has a crisis of faith, spurring the spiritual leaders to compete for her conversion; Glenn wants more respect.

When the hospital runs out of tongue depressors, Owen finds himself tangled in a hospital-wide conspiracy.

Chief hides a race horse at the hospital; Lola's college barbershop quartet tries to convince her to rejoin; Glenn glues Blake's hands in his gloves.

Just Falcon, who plays Dr. Glenn Richie, invites the cast to his photography exhibition, where their secrets are revealed.

The hospital celebrates Bring Your Grandparents to Work Day; the doctors struggle with their relatives.

Owen discovers that the fluid in Chief's hump tastes like Coca-Cola; Blake suspects that Glenn is fighting an addiction.

When Glenn and Owen have bizarre hallucinations, and Lola fears she is being pursued, the doctors believe a gas leak is responsible.