The list of Uruguayan footballers in Serie A records the association football players from Uruguay who have appeared at least once for a team in the Italian Serie A. Entries in bold denote players still active in actual season.

This article includes a list of general references, but it lacks sufficient corresponding inline citations. (October 2021)

• Julio Abbadie – Genoa, Lecco – 1956–62
• Nelson Abeijón – Cagliari, Atalanta – 1998–2000, 2004–07
• Mathías Abero – Bologna – 2012–13
• Carlos Aguilera – Genoa, Torino – 1989–94
• Rodrigo Aguirre – Empoli, Udinese – 2014–16
• Matias Aguirregaray – Palermo – 2011–12^{[b BRA]}
• Vincente Albanese – Bologna – 1937–38
• Emiliano Alfaro – Lazio – 2011–12
• Juan Alberti – Venezia – 1939–47
• Agustín Álvarez – Sassuolo – 2022–23
• Pablo Álvarez – Reggina – 2007–09
• Nicolás Amodio – Napoli – 2008–09
• Germán Antonioli – Fiorentina – 1932–33
• Joaquín Ardaiz – Frosinone – 2018–19
• Felipe Avenatti – Bologna – 2017–18

• Jaime Báez – Cremonese, Frosinone – 2022–
• Raúl Banfi – Modena, Juventus – 1939–40, 1941–42
• Rubén Bentancourt – Atalanta – 2013–14
• Rodrigo Bentancur – Juventus – 2017–22
• Joe Bizera – Cagliari – 2005–08
• Mariano Bogliacino – Napoli, Chievo – 2007–11
• Miguel Britos – Bologna, Napoli – 2008–15
• Gastón Brugman – Palermo, Pescara, Parma – 2015–17, 2019–21

• Leandro Cabrera – Crotone – 2017–18
• Matías Cabrera – Cagliari – 2012–14
• Washington Cacciavillani – Pro Patria, Inter – 1955–56, 1957–58
• Martín Cáceres – Juventus, Verona, Lazio, Fiorentina, Cagliari – 2009–10, 2011–16, 2017–22
• Pablo Cáceres – Torino – 2012–13
• Ricardo Canals – Vicenza – 1997–98
• Nelson Cancela – Atalanta – 1956–57
• Dandolo Candales – Napoli – 1947–48
• Jorge Caraballo – Pisa – 1982–83
• Mathías Cardacio – Milan – 2008–09
• Fabián Carini – Inter, Cagliari – 2004–06
• Jorge Daniel Casanova – Lecce – 1999–2000
• Edinson Cavani – Palermo, Napoli – 2006–13
• Pablo Cepellini – Cagliari – 2010–13
• Angel Cerilla – Napoli – 1947–48
• Javier Chevantón – Lecce, Atalanta – 2001–02, 2003–04, 2009–11
• Alejandro Correa – Brescia – 2000–04
• Sebastián Cristóforo – Fiorentina – 2016–18, 2019–20

• Héctor Demarco – Bologna, Vicenza – 1959–68

• César Falletti – Bologna – 2017–18
• Maximiliano Faotto – Palermo, Lazio, Napoli – 1932–36, 1937–42
• Daniel Fonseca – Cagliari, Napoli, Roma, Juventus, Como – 1990–99, 2000–01, 2002–03
• Diego Forlán – Inter – 2011–12
• Enzo Francescoli – Cagliari, Torino – 1990–94
• José María Franco – Torino – 2001–03
• Ricardo Alberto Frione – Inter – 1932–33

• José García – Bologna, Atalanta – 1949–56
• Pablo García – Milan, Venezia – 2000–02
• Walter Gargano – Napoli, Inter, Parma – 2007–15
• Guillermo Giacomazzi – Lecce, Palermo, Empoli – 2001–02, 2003–09, 2010–12
• Henry Giménez – Bologna – 2009–13
• Diego Godín – Inter, Cagliari – 2019–22
• Mauro Goicoechea – Roma – 2012–13
• Walter Gómez – Palermo – 1956–57
• Alejandro González – Verona, Cagliari – 2013–15
• Álvaro González – Lazio, Torino – 2010–15
• Pablo Granoche – Chievo, Novara – 2009–12
• Carlos Grossmüller – Lecce – 2010–12
• Homero Guaglianone – Lazio – 1960–61
• Gianni Guigou – Roma, Siena, Fiorentina, Treviso – 2000–06
• Nelson Gutiérrez – Lazio, Verona – 1988–90

• Abel Hernández – Palermo – 2008–13
• José Herrera – Cagliari, Atalanta – 1990–97

• Oliviero Icardi – Palermo, Bari – 1935–36, 1937–38
• Salvador Ichazo – Torino – 2014–16, 2018–19

• Luis La Paz – Napoli – 1947–48
• Diego Laxalt – Bologna, Empoli, Genoa, Milan, Torino – 2013–20
• Mauricio Lemos – Sassuolo – 2017–19
• Roberto Leopardi – Genoa, Vicenza – 1957–60
• Norberto Liguera – Bologna – 1937–38
• Diego López – Cagliari – 1998–2000, 2004–10
• Nicolás López – Roma, Udinese, Verona – 2012–15
• Ignacio Lores – Palermo – 2011–12

• Federico Magallanes – Atalanta, Venezia, Torino – 1996–98, 2001–03
• Andrés Martínez – Lecce, Bologna – 1997–98
• Jorge Martínez – Catania, Juventus, Cesena – 2007–12
• Matías Masiero – Genoa – 2007–08
• Alan Matturro – Genoa – 2023–
• Leonardo Melazzi – Genoa – 2012–13
• Gustavo Méndez – Vicenza, Torino – 1995–2000
• Leonardo Migliónico – Sampdoria, Livorno, Lecce – 2007–08, 2009–10, 2011–12
• Paolo Montero – Atalanta, Juventus – 1992–94, 1995–2005
• Romualdo Moro – Napoli – 1956–57
• Fernando Muslera – Lazio – 2007–11^{[b ARG]}

• Nahitan Nández – Cagliari – 2019–22, 2023–

• Fabián O'Neill – Cagliari, Juventus, Perugia – 1995–97, 1998–2002
• Francisco Occhiuzzi – Bologna – 1932–34
• Christian Oliva – Cagliari – 2019–21
• Mathías Olivera – Napoli – 2022–
• Rubén Olivera – Juventus, Sampdoria, Genoa, Lecce, Fiorentina – 2002–03, 2004–05, 2006–09, 2010–14
• Maximiliano Olivera – Fiorentina – 2016–18, 2019–21
• Marcelo Otero – Vicenza – 1995–99

• Antonio Pacheco – Inter – 2000–01
• Rubén Paz – Genoa – 1989–90
• Luis Alberto Pedemonte – Inter – 1946–47
• Horacio Peralta – Cagliari – 2004–05
• José Perdomo – Genoa – 1989–90
• Álvaro Pereira – Inter – 2012–14
• Rubén Pereira – Cremonese – 1991–92
• Gastón Pereiro – Cagliari – 2019–22
• Diego Pérez – Bologna – 2010–14
• Pedro Petrone – Fiorentina – 1931–33
• Diego Polenta – Genoa – 2010–11
• Hugo Esteban Porta – Bologna – 1939–40
• Richard Porta – Siena – 2007–08^{[b AUS][c AUS U17]}

• Gastón Ramírez – Bologna, Sampdoria – 2010–12, 2017–21
• Juan Manuel Ramos – Spezia – 2020–21
• Álvaro Recoba – Inter, Venezia, Torino – 1997–2008
• Nicolas Riccardi – Palermo – 1935–36, 1937–39
• Egidio Arévalo Ríos – Palermo – 2012–13
• Martín Rivas – Inter, Perugia – 1997–99
• Cristian Rodríguez – Parma – 2014–15
• Diego Martín Rodríguez – Udinese – 2012–13
• Diego Rodríguez Da Luz – Bologna – 2008–09
• Federico Rodríguez – Bologna – 2013–14
• Guillermo Rodríguez – Cesena, Torino, Verona – 2011–15
• Ribair Rodríguez – Siena – 2012–13
• Alexis Rolín – Catania – 2012–14
• Marcel Román – Genoa – 2008–09
• Luis Romero – Cagliari – 1996–97

• Marcelo Saralegui – Torino – 1992–93
• Vicente Sarni – Fiorentina – 1932–33
• Martín Satriano – Inter, Empoli – 2021–23
• Héctor Scarone – Inter, Palermo – 1931–35
• Nicolás Schiappacasse – Parma, Sassuolo – 2018–19, 2020–21
• Carlos Servetti – Genoa – 1937–39
• Darío Silva – Cagliari – 1995–97
• Gastón Silva – Torino – 2014–16
• Santiago Silva – Fiorentina – 2011–12
• Gonzalo Sorondo – Inter – 2001–02
• Joaquín Sosa – Bologna – 2022–23
• Rubén Sosa – Lazio, Inter – 1988–95
• Cristhian Stuani – Reggina – 2007–09

• Marcelo Tejera – Cagliari – 1992–93
• Lucas Torreira – Sampdoria, Fiorentina – 2016–18, 2021–22

• Carlos Valdez – Treviso, Reggina – 2005–06, 2007–09
• Matías Vecino – Fiorentina, Cagliari, Empoli, Inter, Lazio – 2013–
• Waldemar Victorino – Cagliari – 1982–83
• Ernesto Vidal – Fiorentina, Pro Patria – 1953–56^{[b CRO–ITA]}
• Matías Viña – Roma, Sassuolo – 2021–24
• Tabaré Viudez – Milan – 2008–09
• Tomaso Luis Volpi – Inter – 1946–47

• Marcelo Zalayeta – Juventus, Empoli, Perugia, Napoli, Bologna – 1997–99, 2001–06, 2007–10
• Bibiano Zapirain – Inter – 1946–48

• List of foreign Serie A players
• List of Uruguayan footballers in Serie B
• Oriundo
• Serie A Foreign Footballer of the Year