The list of Uruguayan footballers in Serie B records the association football players from Uruguay who have appeared at least once for a team in the Italian Serie B. Entries in bold denote players still active in actual season.

• Nelson Abeijón – Cagliari, Como – 2000–04
• Mathías Abero – Avellino, Bologna – 2013–15
• Rodrigo Aguirre – Perugia – 2015–16
• Nicolás Albarracín – Spezia – 2012–14
• Juan Alberti – Palermo – 1936–39
• Matías Alonso – Bari – 2013–14
• Agustín Álvarez – Sampdoria – 2023–
• Nicolás Amodio – Napoli, Treviso, Mantova, Piacenza, Portogruaro – 2006–08, 2009–11
• Gustavo Aprile – Bari – 2012–13
• Maximiliano Arias - Brescia - 2012-13
• Felipe Avenatti – Ternana – 2013–17

• Jaime Báez – Livorno, Spezia, Pescara, Cosenza, Cremonese, Frosinone – 2015–23
• Raúl Banfi – Modena, Mantova, Prato – 1940–41, 1942–43, 1945–47
• Daniel Baldi – Treviso – 2006–07
• Santiago Bellini – Pescara – 2018–19
• Rubén Bentancourt – Bologna – 2014–15
• Mariano Bogliacino – Napoli, Bari – 2006–07, 2011–12
• Nicolás Suárez Bremec – Arezzo, Ascoli, Grosseto, Vicenza – 2005–08, 2012–13, 2014–15^{[b ESP]}
• Gaston Brugman – Empoli, Grosseto, Pescara, Parma – 2010–15, 2017–19, 2021–22

• Pablo Eduardo Caballero – Reggina – 2013–14
• Washington Cacciavillani – Pro Patria – 1956–57
• Gastón Camaño – Empoli – 2011–12
• Jorge Daniel Casanova – Ravenna – 2000–01
• Angel Cerilla – Napoli – 1948–49
• Juan Ignacio Silva Cerón – Triestina – 2006–07
• Javier Chevantón – Lecce – 2002–03

• Juan Delgado – Crotone – 2015–16

• Edgar Elizalde – Pescara – 2017–18, 2019–20

• Cesar Falletti – Ternana, Palermo, Cremonese – 2013–17, 2018–19, 2021–
• Maximilián Faotto – Palermo – 1936–37
• Mateo Figoli – Triestina – 2008–10
• Darío Flores – Perugia – 2014–15
• José María Franco – Torino – 2003–05
• Ricardo Alberto Frione – Sanremese – 1938–39

• Carlos Andrés García – Venezia – 2004–05
• Guillermo Giacomazzi – Lecce, Siena, Perugia – 2002–03, 2006–07, 2009–10, 2013–15
• Henry Damián Giménez – Perugia – 2012–13
• Walter Gomez – Palermo – 1957–58
• Alejandro González – Ternana, Avellino, Perugia – 2015–18
• Facundo González – Sampdoria – 2023–
• Pablo Granoche – Triestina, Varese, Padova, Cesena, Modena, Spezia – 2007–09, 2011–18
• Gianni Guigou – Treviso – 2006–09
• Nelson Gutierrez – Verona – 1990–91

• Abel Hernández – Palermo – 2013–14

• Oliviero Icardi – Palermo, Verona – 1936–37, 1938–40
• Salvador Ichazo – Bari – 2016–17

• Luis La Paz – Napoli – 1948–50
• Norberto Liguera – Anconitana, Bologna – 1938–40
• Marcelo Lipatin – Bari – 2003–05
• Ignacio Lores Varela – Palermo, Bari, Vicenza, Pisa, Ascoli, Cittadella – 2013–15, 2016–18, 2021–23
• Diego López – Cagliari – 2000–04
• Walter Alberto Lopez – Brescia, Benevento, Spezia, Salernitana – 2009–10, 2016–21
• Hernán Rodrigo López – Torino – 1998–99

• Damián Macaluso – Venezia – 2004–05
• Jorge Andrés Martínez – Novara – 2013–14
• Matías Masiero – Pisa – 2008–09
• Gonzalo Mastriani – Crotone – 2013–14
• Alan Matturro – Genoa – 2022–23
• Gustavo Méndez – Torino – 2000–01
• Leonardo Martin Miglionico – Piacenza, Livorno – 2004–09, 2010–12
• Paolo Montero – Atalanta – 1994–95

• Nahitan Nández – Cagliari – 2022–23

• Fabián O'Neill – Cagliari – 1997–98
• Agustín Olivera – Modena – 2015–16
• Rubén Olivera – Brescia, Latina – 2013–16
• Renzo Orihuela – Palermo – 2022–23

• Pablo Pallante – Gallipoli – 2009–10
• Gastón Pereiro – Cagliari, Ternana – 2022–
• Diego Pérez – Bologna – 2014–15
• Diego Perrone – Catania – 2005–06
• Diego Polenta – Bari – 2011–14

• Gastón Ramírez – Monza – 2021–22
• Juan Manuel Ramos – Catania, Spezia – 2014–15, 2019–20
• Nicolas Riccardi – Palermo – 1936–37
• Alexis Rolín – Catania – 2014–15
• Marcel Román – Frosinone – 2008–09

• Andrés Schetino – Cosenza – 2018–19
• Darío Silva – Cagliari – 1997–98
• Cristian Sosa – Gallipoli, Cittadella – 2009–10, 2012–14
• Juan Surraco – Messina, Ancona, Livorno, Modena, Cittadella, Ternana – 2007–15, 2016–17

• Lucas Torreira – Pescara – 2014–16
• Hugo Tortora – Reggiana – 1940–41
• Victor Tortora – Palermo, Venezia – 1936–39, 1945–46

• Carlos Adrián Valdez – Treviso, Reggina, Siena – 2006–07, 2009–11
• Agustín Viana – Gallipoli – 2009–10^{[b USA]}
• Gonzalo Germán Vicente – Venezia – 2004–05

• Marcelo Zalayeta – Juventus – 2006–07

• List of foreign Serie B players
• List of Uruguayan footballers in Serie A