Rootletin

Rootletin

Rootletin

Protein found in humans

Rootletin also known as ciliary rootlet coiled-coil protein (CROCC) is a protein that in humans is encoded by the CROCC gene.[5][6][7] Rootletin is a component of the ciliary rootlet, and, together with CEP68 and CEP250, is required for centrosome cohesion.[8]

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Rootletin is an important protein in the ciliary rootlet, particular for the structure and can be considered an important protein in mitosis as it is a centrosome linker.

Function

This protein forms part of the ciliary rootlet structure. It also helps to contribute to the centrosome cohesion before mitosis.[9] Expression of rooletin leads to the formation of fibrous protein.

Structure

This protein is part of the structure of a ciliary rootlet. This cytoskeletal-like structure starts from the basal body at one end of the cilium and extends towards nucleus. Its molecular structure consists of a globular head domain and a tail domain made up of coiled-coil structures.[5]

Protein interactions

A large coiled-coil protein, C-Nap1, is a docking site for the fibrous tether to proximal ends of centrioles which Rootletin physically interacts with. Furthermore, Rootletin is phosphorylated by Nek2 kinase.[10]

References

  1. [1]
    GRCh38: Ensembl release 89: ENSG00000058453 – Ensembl, May 2017
  2. [2]
    GRCm38: Ensembl release 89: ENSMUSG00000040860 – Ensembl, May 2017
  3. [3]
    "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  4. [4]
    "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
  5. [5]
    Yang J, Liu X, Yue G, Adamian M, Bulgakov O, Li T (Nov 2002). "Rootletin, a novel coiled-coil protein, is a structural component of the ciliary rootlet". J Cell Biol. 159 (3): 431–40. doi:10.1083/jcb.200207153. PMC 2173070. PMID 12427867.
  6. [6]
    McClintock TS, Glasser CE, Bose SC, Bergman DA (Jan 2008). "Tissue expression patterns identify mouse cilia genes". Physiol Genomics. 32 (2): 198–206. doi:10.1152/physiolgenomics.00128.2007. PMID 17971504.
  7. [7]
    "Entrez Gene: CROCC ciliary rootlet coiled-coil, rootletin".
  8. [8]
    Graser S, Stierhof YD, Nigg EA (December 2007). "Cep68 and Cep215 (Cdk5rap2) are required for centrosome cohesion". J. Cell Sci. 120 (Pt 24): 4321–31. doi:10.1242/jcs.020248. PMID 18042621.
  9. [9]
    Bahe S, Stierhof YD, Wilkinson CJ, Leiss F, Nigg EA (October 2005). "Rootletin forms centriole-associated filaments and functions in centrosome cohesion". J. Cell Biol. 171 (1): 27–33. doi:10.1083/jcb.200504107. PMC 2171225. PMID 16203858.
  10. [10]
    Lim HH, Zhang T, Surana U (July 2009). "Regulation of centrosome separation in yeast and vertebrates: common threads". Trends Cell Biol. 19 (7): 325–33. doi:10.1016/j.tcb.2009.03.008. PMID 19576775.

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