Adjacent counties

• Jefferson County, Florida - northwest
• Madison County, Florida - north
• Lafayette County, Florida - east
• Dixie County, Florida - southeast

National protected area

• St. Marks National Wildlife Refuge (part)

2020 census

Note: the US Census treats Hispanic/Latino as an ethnic category. This table excludes Latinos from the racial categories and assigns them to a separate category. Hispanics/Latinos can be of any race.

As of the 2020 United States census, there were 21,796 people, 7,405 households, and 5,197 families residing in the county.

2000 census

As of the census^[16] of 2000, there were 19,256 people, 7,176 households, and 5,130 families residing in the county. The population density was 18 people per square mile (6.9 people/km²). There were 9,646 housing units at an average density of 9 per square mile (3.5/km²). The racial makeup of the county was 77.84% White, 19.04% Black or African American, 0.98% Native American, 0.44% Asian, 0.02% Pacific Islander, 0.32% from other races, and 1.38% from two or more races. 1.53% of the population were Hispanic or Latino of any race.

There were 7,176 households, out of which 31.60% had children under the age of 18 living with them, 52.50% were married couples living together, 14.40% had a female householder with no husband present, and 28.50% were non-families. 24.20% of all households were made up of individuals, and 10.60% had someone living alone who was 65 years of age or older. The average household size was 2.51 and the average family size was 2.95.

In the county, the population was spread out, with 24.60% under the age of 18, 8.20% from 18 to 24, 28.30% from 25 to 44, 24.80% from 45 to 64, and 14.10% who were 65 years of age or older. The median age was 38 years. For every 100 females there were 104.40 males. For every 100 females age 18 and over, there were 104.80 males.

The median income for a household in the county was $30,032, and the median income for a family was $35,061. Males had a median income of $27,967 versus $19,054 for females. The per capita income for the county was $15,281. About 14.50% of families and 18.00% of the population were below the poverty line, including 22.20% of those under age 18 and 17.90% of those age 65 or over.

In March 2016, the county's unemployment rate was 5.6%.

Town

• Perry

Census-designated place

• Steinhatchee

Other unincorporated communities

Airports

• Perry–Foley Airport

Major highways

• US 19
• US 27
• 
  US 27 Alt.
• US 98
• US 221
• SR 51