INSRR

INSRR
Identifiers
Aliases	INSRR, IRR, insulin receptor related receptor
External IDs	OMIM: 147671; MGI: 1346037; HomoloGene: 56539; GeneCards: INSRR; OMA:INSRR - orthologs
Gene location (Human)
Chr.	Chromosome 1 (human)
End	156,859,117 bp
Gene location (Mouse)
Chr.	Chromosome 3 (mouse)
End	87,723,408 bp
RNA expression pattern
	Top expressed in
	body of stomach; ; human kidney; ; body of uterus; ; right testis; ; apex of heart; ; myometrium; ; canal of the cervix; ; fundus; ; left testis; ; abdominal wall;
	Top expressed in
	islet of Langerhans; ; cingulate gyrus; ; internal carotid artery; ; external carotid artery; ; kidney; ; left lobe of liver; ; spinal ganglia; ; crypt of lieberkuhn of small intestine; ; cerebellar cortex; ; hair follicle;
	More reference expression data
	More reference expression data
Gene ontology
Molecular function	transmembrane receptor protein tyrosine kinase activity; phosphatidylinositol 3-kinase binding; insulin receptor substrate binding; nucleotide binding; protein kinase activity; protein tyrosine kinase activity; transferase activity; ATP binding; kinase activity; receptor tyrosine kinase; transmembrane signaling receptor activity; insulin-activated receptor activity;
Cellular component	receptor complex; integral component of membrane; integral component of plasma membrane; membrane; cytoplasm; insulin receptor complex; axon;
Biological process	actin cytoskeleton reorganization; protein autophosphorylation; protein phosphorylation; cellular response to alkaline pH; male sex determination; phosphorylation; transmembrane receptor protein tyrosine kinase signaling pathway; peptidyl-tyrosine phosphorylation; insulin receptor signaling pathway; negative regulation of signal transduction; cell differentiation; glucose homeostasis; negative regulation of apoptotic process; positive regulation of ERK1 and ERK2 cascade; anatomical structure development;
	Sources:Amigo / QuickGO
Orthologs
	3645
	23920
	ENSG00000027644
	ENSMUSG00000005640
	P14616
	Q9WTL4
	NM_014215
	NM_011832
	NP_055030
	NP_035962
	Wikidata
View/Edit Human	View/Edit Mouse

INSRR

Protein-coding gene in the species Homo sapiens

Insulin receptor-related protein is a protein that in humans is encoded by the INSRR gene.^[5]^[6]^[7]

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This article uses material from the Wikipedia article INSRR, and is written by contributors. Text is available under a CC BY-SA 4.0 International License; additional terms may apply. Images, videos and audio are available under their respective licenses.

[refGRCh38Ensembl-1] [1]
GRCh38: Ensembl release 89: ENSG00000027644 – Ensembl, May 2017

[refGRCm38Ensembl-2] [2]
GRCm38: Ensembl release 89: ENSMUSG00000005640 – Ensembl, May 2017

[3] [3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[4] [4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.

[pmid2768234-5] [5]
Shier P, Watt VM (Oct 1989). "Primary structure of a putative receptor for a ligand of the insulin family". J Biol Chem. 264 (25): 14605–8. doi:10.1016/S0021-9258(18)63737-8. PMID 2768234.

[pmid2249481-6] [6]
Shier P, Willard HF, Watt VM (Jan 1991). "Localization of the insulin receptor-related receptor gene to human chromosome 1". Cytogenet Cell Genet. 54 (1–2): 80–1. doi:10.1159/000132963. PMID 2249481.

[entrez-7] [7]
"Entrez Gene: INSRR insulin receptor-related receptor".

[5]

[6]

[7]

[1]

[2]

[3]

[4]

INSRR

INSRR

References

Further reading

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