MGST3
MGST3
Protein-coding gene in the species Homo sapiens
Microsomal glutathione S-transferase 3 is an enzyme that in humans is encoded by the MGST3 gene.[5][6]
Quick Facts Identifiers, Aliases ...
| MGST3 | |||||||||||||||||||||||||||||||||||||||||||||||||||
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| Aliases | MGST3, GST-III, microsomal glutathione S-transferase 3 | ||||||||||||||||||||||||||||||||||||||||||||||||||
| External IDs | OMIM: 604564; MGI: 1913697; HomoloGene: 3327; GeneCards: MGST3; OMA:MGST3 - orthologs | ||||||||||||||||||||||||||||||||||||||||||||||||||
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The MAPEG (Membrane-Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, several of which are involved the production of leukotrienes and prostaglandin E, important mediators of inflammation. This gene encodes an enzyme that catalyzes the conjugation of leukotriene A4 and reduced glutathione to produce leukotriene C4. This enzyme also demonstrates glutathione-dependent peroxidase activity towards lipid hydroperoxides.[6]
- "Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- "Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
- Jakobsson PJ, Mancini JA, Riendeau D, Ford-Hutchinson AW (Oct 1997). "Identification and characterization of a novel microsomal enzyme with glutathione-dependent transferase and peroxidase activities". J Biol Chem. 272 (36): 22934–9. doi:10.1074/jbc.272.36.22934. PMID 9278457.
- Jakobsson PJ, Morgenstern R, Mancini J, et al. (2000). "Membrane-associated proteins in eicosanoid and glutathione metabolism (MAPEG). A widespread protein superfamily". Am. J. Respir. Crit. Care Med. 161 (2 Pt 2): S20–4. doi:10.1164/ajrccm.161.supplement_1.ltta-5. PMID 10673221.
- Kobayashi K, Xin Y, Ymer SI, et al. (2007). "Subtractive hybridisation screen identifies genes regulated by glucose deprivation in human neuroblastoma cells". Brain Res. 1170: 129–39. doi:10.1016/j.brainres.2007.07.042. PMID 17719568. S2CID 31320196.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–21. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Thameem F, Yang X, Permana PA, et al. (2003). "Evaluation of the microsomal glutathione S-transferase 3 (MGST3) locus on 1q23 as a Type 2 diabetes susceptibility gene in Pima Indians". Hum. Genet. 113 (4): 353–8. doi:10.1007/s00439-003-0980-y. PMID 12898215. S2CID 105953.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, et al. (1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
- Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
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