ZBTB17

Protein-coding gene in the species Homo sapiens

Zinc finger and BTB domain-containing protein 17 is a protein that in humans is encoded by the ZBTB17 gene.^[5]

Quick Facts Available structures, PDB ...

ZBTB17

Available structures

Ortholog search: PDBe RCSB

List of PDB id codes
2LVR, 2LVT, 2LVU, 2M0D, 2M0E, 2M0F, 2N25, 2N26, 2Q81, 3M52, 4U2M, 4U2N, 5ION

Identifiers

Aliases

ZBTB17, MIZ-1, ZNF151, ZNF60, pHZ-67, zinc finger and BTB domain containing 17

External IDs

OMIM: 604084; MGI: 107410; HomoloGene: 2575; GeneCards: ZBTB17; OMA:ZBTB17 - orthologs

Gene location (Human)

Chr.	Chromosome 1 (human)^[1]

Band	1p36.13	Start	15,941,869 bp^[1]
Band	1p36.13	End	15,976,132 bp^[1]

Gene location (Mouse)

Chr.	Chromosome 4 (mouse)^[2]

Band	4\|4 D3	Start	141,171,965 bp^[2]
Band	4\|4 D3	End	141,195,241 bp^[2]

RNA expression pattern

Bgee

Human

Mouse (ortholog)

Top expressed in

sural nerve

right lobe of thyroid gland

ganglionic eminence

left lobe of thyroid gland

upper lobe of left lung

spleen

left uterine tube

body of stomach

canal of the cervix

right lung

Top expressed in

saccule

otic placode

plantaris muscle

extensor digitorum longus muscle

interventricular septum

soleus muscle

morula

ganglionic eminence

quadriceps femoris muscle

More reference expression data

BioGPS


More reference expression data

Gene ontology
Molecular function	DNA-binding transcription factor activity DNA binding protein binding metal ion binding nucleic acid binding RNA polymerase II cis-regulatory region sequence-specific DNA binding DNA-binding transcription activator activity, RNA polymerase II-specific transcription coactivator binding transcription factor binding DNA-binding transcription factor activity, RNA polymerase II-specific
Cellular component	nucleus nucleoplasm protein-DNA complex protein-containing complex
Biological process	positive regulation of transcription, DNA-templated multicellular organism development gastrulation with mouth forming second ectoderm development IRE1-mediated unfolded protein response negative regulation of cell cycle regulation of transcription, DNA-templated transcription, DNA-templated transcription by RNA polymerase II negative regulation of cell population proliferation positive regulation of transcription by RNA polymerase II
Sources:Amigo / QuickGO

Orthologs

Species

Human

Mouse

Entrez


7709


22642

Ensembl


ENSG00000116809


ENSMUSG00000006215

UniProt


Q13105


Q60821

RefSeq (mRNA)

NM_001242884 NM_001287603 NM_001287604 NM_003443 NM_001324137
NM_001324138


NM_009541 NM_001378826 NM_001378827 NM_001378828

RefSeq (protein)

NP_001229813 NP_001274532 NP_001274533 NP_001311066 NP_001311067
NP_003434


NP_033567 NP_001365755 NP_001365756 NP_001365757

Location (UCSC)

Chr 1: 15.94 – 15.98 Mb

Chr 4: 141.17 – 141.2 Mb

PubMed search

^[3]

^[4]

Wikidata

View/Edit Human

View/Edit Mouse

Interactions

ZBTB17 has been shown to interact with TOPBP1,^[6] Host cell factor C1^[7] and Myc.^[8]^[9]

References

[1]
GRCh38: Ensembl release 89: ENSG00000116809 – Ensembl, May 2017
[2]
GRCm38: Ensembl release 89: ENSMUSG00000006215 – Ensembl, May 2017
[3]
"Human PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[4]
"Mouse PubMed Reference:". National Center for Biotechnology Information, U.S. National Library of Medicine.
[5]
"Entrez Gene: ZBTB17 zinc finger and BTB domain containing 17".
[6]
Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M (Sep 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Molecular Cell. 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.
[7]
Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry. 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.
[8]
Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (Apr 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nature Cell Biology. 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613. S2CID 12696178.
[9]
Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (Sep 1997). "An alternative pathway for gene regulation by Myc". The EMBO Journal. 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026.

Lichter P, Bray P, Ried T, Dawid IB, Ward DC (Aug 1992). "Clustering of C2-H2 zinc finger motif sequences within telomeric and fragile site regions of human chromosomes". Genomics. 13 (4): 999–1007. doi:10.1016/0888-7543(92)90013-I. PMID 1505991.
Bray P, Lichter P, Thiesen HJ, Ward DC, Dawid IB (Nov 1991). "Characterization and mapping of human genes encoding zinc finger proteins". Proceedings of the National Academy of Sciences of the United States of America. 88 (21): 9563–7. Bibcode:1991PNAS...88.9563B. doi:10.1073/pnas.88.21.9563. PMC 52758. PMID 1946370.
Tommerup N, Vissing H (May 1995). "Isolation and fine mapping of 16 novel human zinc finger-encoding cDNAs identify putative candidate genes for developmental and malignant disorders". Genomics. 27 (2): 259–64. doi:10.1006/geno.1995.1040. PMID 7557990.
Maruyama K, Sugano S (Jan 1994). "Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides". Gene. 138 (1–2): 171–4. doi:10.1016/0378-1119(94)90802-8. PMID 8125298.
Wu L, Wu H, Ma L, Sangiorgi F, Wu N, Bell JR, Lyons GE, Maxson R (Jul 1997). "Miz1, a novel zinc finger transcription factor that interacts with Msx2 and enhances its affinity for DNA". Mechanisms of Development. 65 (1–2): 3–17. doi:10.1016/S0925-4773(97)00032-4. PMID 9256341. S2CID 11835268.
Schneider A, Peukert K, Eilers M, Hänel F (1997). "Association of Myc with the Zinc-finger Protein Miz-1 Defines a Novel Pathway for Gene Regulation by Myc". C-Myc in B-Cell Neoplasia. Current Topics in Microbiology and Immunology. Vol. 224. pp. 137–46. doi:10.1007/978-3-642-60801-8_14. ISBN 978-3-642-64560-0. PMID 9308237.
Peukert K, Staller P, Schneider A, Carmichael G, Hänel F, Eilers M (Sep 1997). "An alternative pathway for gene regulation by Myc". The EMBO Journal. 16 (18): 5672–86. doi:10.1093/emboj/16.18.5672. PMC 1170199. PMID 9312026.
Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S (Oct 1997). "Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library". Gene. 200 (1–2): 149–56. doi:10.1016/S0378-1119(97)00411-3. PMID 9373149.
Sui D, Wilson JE (Oct 2000). "Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase". Archives of Biochemistry and Biophysics. 382 (2): 262–74. doi:10.1006/abbi.2000.2019. PMID 11068878.
Staller P, Peukert K, Kiermaier A, Seoane J, Lukas J, Karsunky H, Möröy T, Bartek J, Massagué J, Hänel F, Eilers M (Apr 2001). "Repression of p15INK4b expression by Myc through association with Miz-1". Nature Cell Biology. 3 (4): 392–9. doi:10.1038/35070076. PMID 11283613. S2CID 12696178.
Ziegelbauer J, Shan B, Yager D, Larabell C, Hoffmann B, Tjian R (Aug 2001). "Transcription factor MIZ-1 is regulated via microtubule association". Molecular Cell. 8 (2): 339–49. doi:10.1016/S1097-2765(01)00313-6. PMID 11545736.
Tussie-Luna MI, Michel B, Hakre S, Roy AL (Nov 2002). "The SUMO ubiquitin-protein isopeptide ligase family member Miz1/PIASxbeta /Siz2 is a transcriptional cofactor for TFII-I". The Journal of Biological Chemistry. 277 (45): 43185–93. doi:10.1074/jbc.M207635200. PMID 12193603.
Piluso D, Bilan P, Capone JP (Nov 2002). "Host cell factor-1 interacts with and antagonizes transactivation by the cell cycle regulatory factor Miz-1". The Journal of Biological Chemistry. 277 (48): 46799–808. doi:10.1074/jbc.M206226200. PMID 12244100.
Zhang H, Li Z, Viklund EK, Strömblad S (Sep 2002). "P21-activated kinase 4 interacts with integrin alpha v beta 5 and regulates alpha v beta 5-mediated cell migration". The Journal of Cell Biology. 158 (7): 1287–97. doi:10.1083/jcb.200207008. PMC 2173231. PMID 12356872.
Herold S, Wanzel M, Beuger V, Frohme C, Beul D, Hillukkala T, Syvaoja J, Saluz HP, Haenel F, Eilers M (Sep 2002). "Negative regulation of the mammalian UV response by Myc through association with Miz-1". Molecular Cell. 10 (3): 509–21. doi:10.1016/S1097-2765(02)00633-0. PMID 12408820.
Wu S, Cetinkaya C, Munoz-Alonso MJ, von der Lehr N, Bahram F, Beuger V, Eilers M, Leon J, Larsson LG (Jan 2003). "Myc represses differentiation-induced p21CIP1 expression via Miz-1-dependent interaction with the p21 core promoter". Oncogene. 22 (3): 351–60. doi:10.1038/sj.onc.1206145. PMID 12545156. S2CID 903258.
Bowen H, Lapham A, Phillips E, Yeung I, Alter-Koltunoff M, Levi BZ, Perry VH, Mann DA, Barton CH (Sep 2003). "Characterization of the murine Nramp1 promoter: requirements for transactivation by Miz-1". The Journal of Biological Chemistry. 278 (38): 36017–26. doi:10.1074/jbc.M304301200. PMID 12840021.
Sakurai T, Itoh K, Higashitsuji H, Nagao T, Nonoguchi K, Chiba T, Fujita J (Apr 2004). "A cleaved form of MAGE-A4 binds to Miz-1 and induces apoptosis in human cells". The Journal of Biological Chemistry. 279 (15): 15505–14. doi:10.1074/jbc.M310437200. hdl:2433/147540. PMID 14739298.
Lehner B, Sanderson CM (Jul 2004). "A protein interaction framework for human mRNA degradation". Genome Research. 14 (7): 1315–23. doi:10.1101/gr.2122004. PMC 442147. PMID 15231747.

External links

ZBTB17+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH)
Overview of all the structural information available in the PDB for UniProt: Q13105 (Zinc finger and BTB domain-containing protein 17) at the PDBe-KB.

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ZBTB17

Interactions

References

Further reading

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