Technique recovers lost single-cell RNA-sequencing information

Boosting the efficiency of single-cell RNA-sequencing helps reveal subtle differences between healthy and dysfunctional cells.

Anne Trafton | MIT News Office • mit
Oct. 13, 2020 ~7 min

chemistry broad-institute ragon-institute research school-of-engineering school-of-science national-institutes-of-health-nih koch-institute institute-for-medical-engineering-and-science-imes

At-home COVID-19 test study launches in Boston

The TestBoston study will facilitate at-home testing on 10,000 people for both the SARS-CoV-2 virus and antibodies against it to increase access to testing and surveillance.

Haley Bridger • harvard
Oct. 6, 2020 ~5 min

covid-19 health-medicine brigham-and-womens-hospital broad-institute sars-cov-2 covid-tests testboston

Rapid test for Covid-19 shows improved sensitivity

A CRISPR-based test developed at MIT and the Broad Institute can detect nearly as many cases as the standard Covid-19 diagnostic.

Anne Trafton | MIT News Office • mit
Sept. 17, 2020 ~5 min

medicine crispr public-health covid-19 pandemic broad-institute viruses research school-of-engineering school-of-science brain-and-cognitive-sciences biological-engineering mcgovern-institute

Mapping the brain’s sensory gatekeeper

New analysis could help uncover potential drug targets for attention deficits and sensory hypersensitivity.

Anne Trafton | MIT News Office • mit
July 22, 2020 ~7 min

neuroscience mental-health autism broad-institute research school-of-science brain-and-cognitive-sciences national-institutes-of-health-nih mcgovern-institute

Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA

Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.

David Orenstein | Picower Institute for Learning and Memory • mit
July 21, 2020 ~7 min

neuroscience rna immunology broad-institute research cells school-of-science brain-and-cognitive-sciences computer-science-and-artificial-intelligence-laboratory-csail picower-institute huntingtons

Lessons from a pandemic

Seven researchers discuss the importance of COVID-19 research and pandemic preparedness, the value of teamwork, and the fragility of life.

lan Mochari, Namrata Sengupta, Kelsey Tsipis • harvard
July 17, 2020 ~17 min

covid-19 coronavirus pandemic health-medicine broad-institute anna-greka benjamin-gewurz deb-hung marcia-goldberg michael-gillette pradeep-natarajan roby-bhattacharyya

Engineers use “DNA origami” to identify vaccine design rules

In lab tests, virus-like DNA structures coated with viral proteins provoke a strong immune response in human B cells.

Anne Trafton | MIT News Office • mit
June 29, 2020 ~7 min

covid-19 broad-institute ragon-institute vaccines research school-of-engineering national-institutes-of-health-nih materials-science-and-engineering dmse biological-engineering koch-institute


Research highlights immune molecule’s complex role in Huntington’s disease

Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes.

David Orenstein | Picower Institute for Learning and Memory • mit
June 8, 2020 ~4 min

neuroscience immunology broad-institute disease research school-of-science brain-and-cognitive-sciences picower-institute

/

10