Engineers use “DNA origami” to identify vaccine design rules

In lab tests, virus-like DNA structures coated with viral proteins provoke a strong immune response in human B cells.

Anne Trafton | MIT News Office • mit
June 29, 2020 ~7 min

Tags: covid-19 broad-institute ragon-institute vaccines research school-of-engineering national-institutes-of-health-nih materials-science-and-engineering dmse biological-engineering koch-institute

Research highlights immune molecule’s complex role in Huntington’s disease

Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes.

David Orenstein | Picower Institute for Learning and Memory • mit
June 8, 2020 ~4 min

Tags: neuroscience immunology broad-institute disease research school-of-science brain-and-cognitive-sciences picower-institute

Synthetic microbial system developed to find objects’ origin

DNA-barcoded microbial spores can trace origin of objects, agricultural products.

Kevin Jiang • harvard
June 4, 2020 ~10 min

Tags: science-technology basic-research broad-institute sherlock probiotic dna-barcodes dna-barcoded-microbial-system foodborne-illnesses

Scientists find a new way to reverse symptoms of Fragile X

Drug compound, tested in mice, could be effective in treating the leading heritable cause of intellectual disability and autism.

Anne Trafton | MIT News Office • mit
May 20, 2020 ~8 min

Tags: medicine autism broad-institute research school-of-science brain-and-cognitive-sciences picower-institute

A connection between ancestry and the molecular makeup of cancer

A new study takes the most comprehensive look to date at the connection between the ancestry and the molecular makeup of cancer.

Rob Levy • harvard
May 11, 2020 ~7 min

Tags: cancer basic-research health-medicine tumors broad-institute human-genome-project ancestry nci-cancer-genome-analysis-network

SHERLOCK-based one-step test provides rapid and sensitive Covid-19 detection

New CRISPR-based research tool delivers results in an hour; researchers share protocol and kits to advance research and move toward clinical validation.

Sabbi Lall | McGovern Institute for Brain Research • mit
May 5, 2020 ~8 min

Tags: dna medicine crispr public-health covid-19 pandemic broad-institute viruses research school-of-science brain-and-cognitive-sciences health-science-and-technology

New technology could provide rapid detection of COVID-19

The CRISPR-based molecular diagnostics chip’s capacity ranges from detecting a single type of virus in more than 1,000 samples at a time to searching a small number of samples for more than 160 different viruses, including the COVID-19 virus.

Karen Zusi • harvard
April 29, 2020 ~8 min

Tags: science-technology engineering covid-19 basic-research broad-institute carmen combinatorial-arrayed-reactions-for-multiplexed-evaluation-of-nucleic-acids crispr-based

Researchers identify cells likely targeted by Covid-19 virus

Study finds specific cells in the lungs, nasal passages, and intestines that are more susceptible to infection.

Anne Trafton | MIT News Office • mit
April 22, 2020 ~9 min

Tags: chemistry covid-19 broad-institute ragon-institute disease viruses research school-of-engineering school-of-science national-institutes-of-health-nih koch-institute institute-for-medical-engineering-and-science-imes

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