Machine learning uncovers potential new TB drugs
Computational method for screening drug compounds can help predict which ones will work best against tuberculosis or other diseases.
Oct. 15, 2020 • ~7 min
machine-learning mathematics medicine drug-discovery artificial-intelligence broad-institute research school-of-engineering school-of-science electrical-engineering-computer-science-eecs computer-science-and-artificial-intelligence-laboratory-csail biological-engineering mit-schwarzman-college-of-computing
Technique recovers lost single-cell RNA-sequencing information
Boosting the efficiency of single-cell RNA-sequencing helps reveal subtle differences between healthy and dysfunctional cells.
Oct. 13, 2020 • ~7 min
chemistry broad-institute ragon-institute research school-of-engineering school-of-science national-institutes-of-health-nih koch-institute institute-for-medical-engineering-and-science-imes
At-home COVID-19 test study launches in Boston
The TestBoston study will facilitate at-home testing on 10,000 people for both the SARS-CoV-2 virus and antibodies against it to increase access to testing and surveillance.
Oct. 6, 2020 • ~5 min
covid-19 health-medicine brigham-and-womens-hospital broad-institute sars-cov-2 covid-tests testboston
Rapid test for Covid-19 shows improved sensitivity
A CRISPR-based test developed at MIT and the Broad Institute can detect nearly as many cases as the standard Covid-19 diagnostic.
Sept. 17, 2020 • ~5 min
medicine crispr public-health covid-19 pandemic broad-institute viruses research school-of-engineering school-of-science brain-and-cognitive-sciences biological-engineering mcgovern-institute
Mapping the brain’s sensory gatekeeper
New analysis could help uncover potential drug targets for attention deficits and sensory hypersensitivity.
July 22, 2020 • ~7 min
neuroscience mental-health autism broad-institute research school-of-science brain-and-cognitive-sciences national-institutes-of-health-nih mcgovern-institute
Neural vulnerability in Huntington’s disease tied to release of mitochondrial RNA
Unique survey of gene expression by cell type in humans and mice reveals several deficits affecting the most vulnerable neurons.
July 21, 2020 • ~7 min
neuroscience rna immunology broad-institute research cells school-of-science brain-and-cognitive-sciences computer-science-and-artificial-intelligence-laboratory-csail picower-institute huntingtons
Lessons from a pandemic
Seven researchers discuss the importance of COVID-19 research and pandemic preparedness, the value of teamwork, and the fragility of life.
July 17, 2020 • ~17 min
covid-19 coronavirus pandemic health-medicine broad-institute anna-greka benjamin-gewurz deb-hung marcia-goldberg michael-gillette pradeep-natarajan roby-bhattacharyya
Engineers use “DNA origami” to identify vaccine design rules
In lab tests, virus-like DNA structures coated with viral proteins provoke a strong immune response in human B cells.
June 29, 2020 • ~7 min
covid-19 broad-institute ragon-institute vaccines research school-of-engineering national-institutes-of-health-nih materials-science-and-engineering dmse biological-engineering koch-institute
The connection between microbes and cholesterol levels
Researchers discover mysterious bacteria that break it down in the gut.
June 24, 2020 • ~6 min
science-technology chemistry heart-disease bacteria emily-balskus chemistry-and-chemical-biology broad-institute caitlin-mcdermott-murphy microbiome microbes gut microbiology ramnik-xavier center-for-microbiome-informatics-and-therapeutics cholesterol cell-host-and-microbe coprostanol damian-plichta douglas-kenny metagenomics
Research highlights immune molecule’s complex role in Huntington’s disease
Knocking out the immune cytokine IL-6 exacerbates symptoms in HD model mice, affects neural connection genes.
June 8, 2020 • ~4 min
neuroscience immunology broad-institute disease research school-of-science brain-and-cognitive-sciences picower-institute
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