90% of drugs fail clinical trials – here's one way researchers can select better drug candidates

Drug development is a long and costly process that often ends in failure. Improving the way potential drug candidates are optimized could help boost success rates.

Duxin Sun, Professor of Pharmaceutical Sciences, University of Michigan • conversation
Feb. 23, 2022 ~10 min

Medical technologies have been central to US pandemic response – but social behaviors matter just as much

Vaccines and medical treatments can only go so far in an unequal society. Facing the ongoing history of racial discrimination and bias in the US would help end the pandemic.

Eyal Oren, Professor of Epidemiology, San Diego State University • conversation
Dec. 22, 2021 ~11 min


How effective are vaccines against omicron? An epidemiologist answers 6 questions

For a number of reasons, as time goes on vaccines become less effective. So how do researchers calculate how well vaccines are working?

Melissa Hawkins, Professor of Public Health, American University • conversation
Dec. 15, 2021 ~9 min

The FDA's lax oversight of research in developing countries can do harm to vulnerable participants

Regulatory loopholes for research conducted off US soil allow for questionable trials and misleading data to slip under the FDA’s radar.

C. Michael White, Distinguished Professor and Head of the Department of Pharmacy Practice, University of Connecticut • conversation
Nov. 12, 2021 ~5 min

What does full FDA approval of a vaccine do if it's already authorized for emergency use?

While emergency use authorization gets vaccines out to the public more quickly, it doesn’t skip any steps that full approval requires.

Jennifer Girotto, Associate Clinical Professor of Pharmacy Practice, University of Connecticut • conversation
Aug. 11, 2021 ~5 min

From CRISPR to glowing proteins to optogenetics – scientists' most powerful technologies have been borrowed from nature

Three pioneering technologies have forever altered how researchers do their work and promise to revolutionize medicine, from correcting genetic disorders to treating degenerative brain diseases.

Marc Zimmer, Professor of Chemistry, Connecticut College • conversation
Aug. 5, 2021 ~9 min

New COVID-19 vaccine warnings don't mean it's unsafe – they mean the system to report side effects is working

Ongoing tracking is meant to spot very rare risks – like the connection between the Johnson & Johnson shot and Guillain-Barré syndrome. And it relies on public reporting.

Justin Vesser, Manager of Ambulatory Pharmacy Services, University of Virginia • conversation
July 19, 2021 ~9 min

Kids aren't just littler adults – here's why they need their own clinical trials for a COVID-19 vaccine

As many teens and adults in the US restart their social lives, parents of children under the age of 12 wonder when their kids will also be able to experience the freedom that comes with vaccination.

Judy Martin, Professor of Pediatrics, University of Pittsburgh • conversation
July 16, 2021 ~10 min


The FDA's big gamble on the new Alzheimer's drug

The FDA approved Alzheimer's disease drug aducanumab despite minimal evidence of its efficacy. Whether this decision ultimately hurts or helps patients depends on data researchers don't yet have.

C. Michael White, Distinguished Professor and Head of the Department of Pharmacy Practice, University of Connecticut • conversation
June 10, 2021 ~10 min

Cambridge leads trial to see if tapeworm drug can boost protection from COVID-19 among vulnerable

UK researchers are launching a clinical trial to investigate if the drug niclosamide, usually used to treat tapeworms, can prevent COVID-19 infection in

Cambridge University News • cambridge
March 22, 2021 ~5 min

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