Search algorithm reveals nearly 200 new kinds of CRISPR systems

By analyzing bacterial data, researchers have discovered thousands of rare new CRISPR systems that have a range of functions and could enable gene editing, diagnostics, and more.

Allessandra DiCorato | Broad Institute • mit
Nov. 23, 2023 ~8 min

Making genetic prediction models more inclusive

MIT computer scientists developed a way to calculate polygenic scores that makes them more accurate for people across diverse ancestries.

Anne Trafton | MIT News • mit
Oct. 26, 2023 ~9 min


Cracking the code that relates brain and behavior in a simple animal

MIT researchers model and create an atlas for how neurons of the worm C. elegans encode its behaviors, make findings available on their “WormWideWeb.”

David Orenstein | The Picower Institute for Learning and Memory • mit
Aug. 23, 2023 ~9 min

Cancer evolution is mathematical – how random processes and epigenetics can explain why tumor cells shape-shift, metastasize and resist treatments

An epigenetic model of cancer that incorporates the concept of stochasticity could also explain why cancer risk increases with age and how biological development can be reversible.

Andrew Feinberg, Professor of Biomedical Engineering, Johns Hopkins University • conversation
Feb. 10, 2023 ~8 min

An interdisciplinary journey through living machines

With NEET, Sherry Nyeo is discovering MIT’s undergraduate research community at the intersection of computer science and biological engineering.

Jiyoo Jye | New Engineering Education Transformation (NEET) program • mit
Oct. 18, 2022 ~5 min

New CRISPR-based map ties every human gene to its function

Jonathan Weissman and collaborators used their single-cell sequencing tool Perturb-seq on every expressed gene in the human genome, linking each to its job in the cell.

Eva Frederick | Whitehead Institute • mit
June 9, 2022 ~9 min

New computational tool predicts cell fates and genetic perturbations

The technique can help predict a cell’s path over time, such as what type of cell it will become.

Greta Friar | Whitehead Institute • mit
Feb. 3, 2022 ~9 min

Charting changes in a pathogen's genome yields clues about its past and hints about its future

After a nose swab tests positive for a virus or bacteria, scientists can use the sample’s genetic sequence to figure out where and when the pathogen emerged and how fast it’s changing.

Sarah Nadeau, PhD Student in Computational Evolution, Swiss Federal Institute of Technology Zurich • conversation
Dec. 1, 2021 ~10 min


The music of proteins is made audible through a computer program that learns from Chopin

Many features of proteins are analogous to music. Mapping these features together creates new musical compositions that help researchers learn about proteins.

Yuzong Chen, Professor of Pharmacy, National University of Singapore • conversation
Sept. 29, 2021 ~6 min

Scientists tap the world's most powerful computers in the race to understand and stop the coronavirus

Scanning through billions of chemicals to find a few potential drugs for treating COVID-19 requires computers that harness together thousands of processors.

Jeremy Smith, Governor's Chair, Biophysics, University of Tennessee • conversation
June 3, 2020 ~9 min

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