‘Pac-Man with a ponytail’ proteins regulate everything from night vision to heartbeats – studying what GRKs look like could improve an array of drugs
Master switches of cell communication, G protein-coupled receptor kinases are the target of many drugs across a range of diseases.
March 7, 2025 • ~7 min
Philly’s street fentanyl contains an industrial chemical called BTMPS that’s an ingredient in plastic
More than half of the street fentanyl samples collected in November 2024 contained BTMPS, and many contained more BTMPS than fentanyl.
March 6, 2025 • ~6 min
Study suggests new molecular strategy for treating fragile X syndrome
Enhancing activity of a specific component of neurons’ “NMDA” receptors normalized protein synthesis, neural activity, and seizure susceptibility in the hippocampus of fragile X lab mice.
March 4, 2025 • ~7 min
p53 is both your genome’s guardian and weakness against cancer – scientists are trying to repair or replace it when it goes awry
The gene that codes for p53 is the most frequently mutated in cancer. Researchers are targeting different parts of its complex pathway to restore its ability to stop cancer.
Feb. 20, 2025 • ~7 min
How opioid deaths tripled in Philly over a decade − and what may be behind a recent downturn
After nearly a decade of annual upticks in overdose deaths, the city saw a drop in 2023, the latest data available. Something may finally be working − but what?
Feb. 11, 2025 • ~9 min
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