Using AI to optimize for rapid neural imaging

MIT CSAIL researchers combine AI and electron microscopy to expedite detailed brain network mapping, aiming to enhance connectomics research and clinical pathology.

Rachel Gordon | MIT CSAIL • mit
Nov. 6, 2023 ~7 min

An itching paradox – a molecule that triggers the urge to scratch also turns down inflammation in the skin

Itch-sensing neurons in your skin are intertwined with your immune cells. Counterintuitively, the molecule that connects them triggers responses that both worsen and improve skin conditions.

Marlys Fassett, Associate Professor of Dermatology, University of California, San Francisco • conversation
Oct. 13, 2023 ~7 min


How a single neuron’s parallel outputs can coordinate many aspects of behavior

Study finds that in worms, the HSN neuron uses multiple chemicals and connections to orchestrate egg-laying and locomotion over the course of several minutes.

David Orenstein | The Picower Institute for Learning and Memory • mit
Oct. 3, 2023 ~7 min

Psychedelics plus psychotherapy can trigger rapid changes in the brain − new research at the level of neurons is untangling how

Change in the brain usually comes with plenty of effort over time. Neuroscientists are working to understand how psychedelic drugs provide a shortcut that seems to rely on existing brain systems.

Edmund S. Higgins, Affiliate Associate Professor of Psychiatry & Family Medicine, Medical University of South Carolina • conversation
Oct. 2, 2023 ~8 min

Human brain too big to map so they’re starting with mice

Harvard-led project seeks to create the first comprehensive diagram of every neural connection.

Anne Manning • harvard
Sept. 26, 2023 ~8 min

Individual neurons mix multiple RNA edits of key synapse protein, study finds

Neurons stochastically generated up to eight different versions of a protein-regulating neurotransmitter release, which could vary how they communicate with other cells.

David Orenstein | The Picower Institute for Learning and Memory • mit
Sept. 25, 2023 ~7 min

Dopamine is a brain chemical famously linked to mood and pleasure − but researchers have found multiple types of dopamine neurons with different functions

From dopamine hacking to dopamine detoxes, some people have sought to harness this brain chemical to improve their mood and productivity. But it’s far more complicated than that.

Kimberlee D'Ardenne, Assistant Research Professor in Psychology, Arizona State University • conversation
Sept. 18, 2023 ~9 min

Study connects neural gene expression differences to functional distinctions

Researchers compared a pair of superficially similar motor neurons in fruit flies to examine how their differing use of the same genome produced distinctions in form and function.

David Orenstein | The Picower Institute for Learning and Memory • mit
Aug. 25, 2023 ~8 min


Cracking the code that relates brain and behavior in a simple animal

MIT researchers model and create an atlas for how neurons of the worm C. elegans encode its behaviors, make findings available on their “WormWideWeb.”

David Orenstein | The Picower Institute for Learning and Memory • mit
Aug. 23, 2023 ~9 min

Could brain ‘glue’ help people stay awake without getting tired?

Research in mice suggests that brain cells called astrocytes could be key to staying awake without cost to cognition or health.

Judith Van Dongen-Washington State • futurity
Aug. 21, 2023 ~6 min

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