Cells have more mini ‘organs’ than researchers thought − unbound by membranes, these rogue organelles challenge biology’s fundamentals

Membraneless organelles, also called biomolecular condensates, are changing how scientists think about protein chemistry, various diseases and even the origin of life.

Allan Albig, Associate Professor of Biological Sciences, Boise State University • conversation
Nov. 5, 2024 ~8 min

Killing the messenger

A newly characterized anti-viral defense system in bacteria aborts infection through a novel mechanism by chemically altering mRNA.

Lillian Eden | Department of Biology • mit
Nov. 1, 2024 ~7 min


MicroRNA − a new Nobel laureate describes the scientific process of discovering these tiny molecules that turn genes on and off

Victor Ambros received half of the Nobel Prize for his work on microRNAs. Here he talks about the teamwork – and the nematodes – that made the discovery possible.

Victor Ambros, Professor of Molecular Medicine, UMass Chan Medical School • conversation
Oct. 17, 2024 ~12 min

Rain may have helped form the first cells, kick-starting life as we know it

The earliest cells likely didn’t have membranes to separate and protect their components and chemistry away from a harsh surrounding environment. But they may have made do with rain.

Aman Agrawal, Postdoctoral Scholar in Chemical Engineering, University of Chicago Pritzker School of Molecular Engineering • conversation
Oct. 15, 2024 ~12 min

Cancer biologists discover a new mechanism for an old drug

Study reveals the drug, 5-fluorouracil, acts differently in different types of cancer — a finding that could help researchers design better drug combinations.

Anne Trafton | MIT News • mit
Oct. 7, 2024 ~9 min

MicroRNA is the Nobel-winning master regulator of the genome – researchers are learning to treat disease by harnessing how it controls genes

Victor Ambros and Gary Ruvkun won the 2024 Nobel Prize in physiology or medicine for their discovery of microRNAs, molecules that turn genes on and off – and cause disease when they go awry.

Andrea Kasinski, Associate Professor of Biological Sciences, Purdue University • conversation
Oct. 7, 2024 ~9 min

A new way to reprogram immune cells and direct them toward anti-tumor immunity

MIT scientists’ discovery yields a potent immune response, could be used to develop a potential tumor vaccine.

Danielle Randall Doughty | Department of Chemistry • mit
Sept. 16, 2024 ~6 min

Study across multiple brain regions discerns Alzheimer’s vulnerability and resilience factors

Genomics and lab studies reveal numerous findings, including a key role for Reelin amid neuronal vulnerability, and for choline and antioxidants in sustaining cognition.

David Orenstein | The Picower Institute for Learning and Memory • mit
July 24, 2024 ~11 min


New technique reveals how gene transcription is coordinated in cells

By capturing short-lived RNA molecules, scientists can map relationships between genes and the regulatory elements that control them.

Anne Trafton | MIT News • mit
June 5, 2024 ~8 min

Unravelling life’s origin: five key breakthroughs from the past five years

The origin of life on Earth is one of the biggest mysteries in science.

Louise Gillet de Chalonge, PhD Student in Astrobiology, Dublin City University • conversation
May 2, 2024 ~9 min

/

16