How cancer cells can become immortal – new research finds a mutated gene that helps melanoma defeat the normal limits on repeated replication
One enzyme plays a key role in how tumor cells replicate and divide indefinitely. Identifying the genes that give these cells their immortality could provide new drug targets to treat cancer.
Jonathan Alder, Assistant Professor of Medicine, University of Pittsburgh Health Sciences •
conversation
Nov. 10, 2022 • ~6 min
Nov. 10, 2022 • ~6 min
Cells become zombies when the ends of their chromosomes are damaged – a tactic both helpful and harmful for health
The protective caps at the ends of chromosomes naturally shorten over time. Researchers found that direct damage can prematurely trigger senescence and contribute to age-related diseases like cancer.
Ryan Barnes, Postdoctoral Researcher in Environmental and Occupational Health, University of Pittsburgh Health Sciences •
conversation
July 19, 2022 • ~6 min
July 19, 2022 • ~6 min
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