Flaws emerge in modeling human genetic diseases in animals

Recent studies using CRISPR to fast-track genetic studies into human disease genes appear flawed.

Gage Crump, Professor of Stem Cell Biology and Regenerative Medicine, University of Southern California • conversation
Nov. 10, 2020 • ~8 min

 genetics  crispr  biology  zebrafish  embryology  genetic-diseases

Nobel prize: who gets left out?

Emmanuelle Charpentier and Jennifer Doudna were awarded the Nobel prize in chemistry for Crispr but they weren't the only key figures in its development.

Rebecca Owens, PhD Candidate in Intellectual Property Law, University of Liverpool • conversation
Oct. 8, 2020 • ~4 min
crispr nobel-prize prizes nobel-prize-2020 nobel-prize-in-chemistry

Nobel Prize for chemistry honors exquisitely precise gene-editing technique, CRISPR – a gene engineer explains how it works

The tools to rewrite the genetic code to improve crops and livestock, or to treat genetic diseases, has revolutionized biology. A CRISPR engineer explains why this technology won the Nobel, and its potential.

Piyush K. Jain, Assistant Professor of Chemical Engineering, Herbert Wertheim College of Engineering, UF Health Cancer Center, University of Florida • conversation
Oct. 7, 2020 • ~8 min

 crispr  nobel-prize  agriculture  gene-editing  nobel-prize-2020  nobel-prize-in-chemistry  gene-edited-babies  gene-edited-livestock

Nobel Prize for CRISPR honors two great scientists – and leaves out many others

Most scientific discoveries these days aren't easily ascribed to a single researcher. CRISPR is no different – and ongoing patent fights underscore how messy research can be.

Marc Zimmer, Professor of Chemistry, Connecticut College • conversation
Oct. 7, 2020 • ~9 min
dna crispr gene-editing genome-editing crisprcas patents nobel-prize-2020 crisprcas9 yogurt nobel-prize-in-chemistry

CRISPR can help combat the troubling immune response against gene therapy

The immune system is trained to destroy viruses, even when they carry therapeutic cargo as is the case in gene therapy. Now researchers have figured out how to dial down the immune response.

Samira Kiani, Associate Professor of Pathology, University of Pittsburgh • conversation
Sept. 3, 2020 • ~7 min

 innovation  health  medicine  crispr  inflammation  immune-system  gene-therapy  gene-editing  viruses  steroids

How gene editing a person's brain cells could be used to curb the opioid epidemic

A person dies of opioid overdose once every 13 minutes in the US. A researcher proposes a way using existing technology to remove the opioid target in people to prevent overdoses.

Craig W. Stevens, Professor of Pharmacology, Oklahoma State University • conversation
Aug. 5, 2020 • ~9 min

 crispr  opioid  gene-editing  morphine  crisprcas  endorphins  analgesic  oxycodone

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