Drilling down on treatment-resistant fungi with molecular machines

Fungal infections can be among the hardest to treat, and since the pandemic began they’ve become only more common. To prevent future antifungal resistance, scientists have developed tiny molecular drills.

James Tour, Professor of Chemistry, Rice University • conversation
May 26, 2023 ~9 min

Vaccines using mRNA can protect farm animals against diseases traditional ones may not – and there are safeguards to ensure they won't end up in your food

While mRNA vaccines are designed to last longer in the body than mRNA molecules typically would, they are also tested to ensure they are eliminated from livestock long before milking or slaughter.

David Verhoeven, Assistant Professor of Vet Microbiology and Preventive Medicine, Iowa State University • conversation
May 17, 2023 ~10 min


How do _Candida auris_ and other fungi develop drug resistance? A microbiologist explains

Multidrug-resistant fungal infections are an emerging global health threat. Figuring out how fungi evade treatments offers new avenues to counter resistance.

Jeffrey Gardner, Associate Professor of Biological Sciences, University of Maryland, Baltimore County • conversation
May 3, 2023 ~7 min

Cells routinely self-cannibalize to take out their trash, aiding in survival and disease prevention

Cells degrade and recycle damaged parts of themselves through a process called autophagy. When this “self-devouring” goes awry, it may promote cancer and neurodegenerative disease.

Justin Quiles, Postdoctoral Scholar of Pharmacy and Pharmaceutical Science, University of California, San Diego • conversation
Feb. 8, 2023 ~9 min

How do you make a universal flu vaccine? A microbiologist explains the challenges, and how mRNA could offer a promising solution

Annual flu vaccines are in a constant race against a rapidly mutating virus that may one day cause the next pandemic. A one-time vaccine protecting against all variants could give humanity a leg up.

Deborah Fuller, Professor of Microbiology, School of Medicine, University of Washington • conversation
Feb. 7, 2023 ~8 min

Organ-on-a-chip models allow researchers to conduct studies closer to real-life conditions – and possibly grease the drug development pipeline

Successes in the lab mostly don’t translate to people. Research models that better mimic the human body could close the gap.

Chengpeng Chen, Assistant Professor of Chemistry and Biochemistry, University of Maryland, Baltimore County • conversation
Jan. 10, 2023 ~7 min

Nanomedicines for various diseases are in development – but research facilities produce vastly inconsistent results on how the body will react to them

The proteins that cover nanoparticles are essential to understanding how they work in the body. Across 17 proteomics facilities in the US, less than 2% of the identified proteins were identical.

Morteza Mahmoudi, Assistant Professor of Radiology, Michigan State University • conversation
Jan. 5, 2023 ~5 min

Drugs – 4 essential reads on how they're made, how they work and how context can make poison a medicine

Despite technological advancements, many challenges remain in getting a drug from lab to pharmacy shelf. Reframing what is a “medicine” could expand treatment options for researchers and patients.

Vivian Lam, Assistant Health and Biomedicine Editor • conversation
Oct. 26, 2022 ~9 min


Male birth control options are in development, but a number of barriers still stand in the way

There hasn’t been a new form of male birth control since the 1980s. More contraception options for all partners could help reduce the rate of unintended pregnancies.

Christina Chung-Lun Wang, Physician/Investigator at Lundquist Institute at Harbor-UCLA Medical Center and Professor of Medicine at David Geffen School of Medicine, University of California, Los Angeles • conversation
Oct. 12, 2022 ~8 min

Many drugs have mirror image chemical structures – while one may be helpful, the other may be harmful

From thalidomide to resveratrol, molecules with the exact same chemical properties can have drastically different effects in the body depending on how they’re arranged in space.

Sajish Mathew, Assistant Professor of Drug Discovery and Biomedical Sciences, University of South Carolina • conversation
Aug. 3, 2022 ~7 min

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