Will AI revolutionize drug development? Researchers explain why it depends on how it’s used

Researchers have applied AI to every step of the drug development process. But this might not be enough to design safe and effective drugs.

Christian Macedonia, Adjunct Professor in Pharmaceutical Sciences, University of Michigan • conversation
Jan. 3, 2025 ~9 min

An AI tool for predicting protein shapes could be transformative for medicine, but it challenges science’s need for proof

Science has a need to verify results, but DeepMind’s protein prediction tool doesn’t work this way.

Sam McKee, Tutor and researcher in Philosophy of Science, Manchester Metropolitan University • conversation
May 31, 2024 ~7 min


AI system can predict the structures of life’s molecules with stunning accuracy – helping to solve one of biology’s biggest problems

The AI model can predict structures for a vast array of the proteins used by living organisms.

Richard Bayliss, Professor of Molecular Medicine, School of Molecular and Cellular Biology, University of Leeds • conversation
May 10, 2024 ~8 min

Drugs that aren’t antibiotics can also kill bacteria − new method pinpoints how

There are many ways to kill microbes that cause dangerous infections. Combining genetic screening with machine learning can help researchers identify new antimicrobials.

Mariana Noto Guillen, Ph.D. Candidate in Systems Biology, UMass Chan Medical School • conversation
April 16, 2024 ~7 min

Reconstructing ancient bacterial genomes can revive previously unknown molecules – offering a potential source for new antibiotics

Ancient microbes likely produced natural products their descendants today do not. Tapping into this lost chemical diversity could offer a potential source of new drugs.

Pierre Stallforth, Professor of Bioorganic Chemistry and Paleobiotechnology, Friedrich-Schiller-Universität Jena • conversation
May 4, 2023 ~9 min

Drugs – 4 essential reads on how they're made, how they work and how context can make poison a medicine

Despite technological advancements, many challenges remain in getting a drug from lab to pharmacy shelf. Reframing what is a “medicine” could expand treatment options for researchers and patients.

Vivian Lam, Assistant Health and Biomedicine Editor • conversation
Oct. 26, 2022 ~9 min

Nature is the world's original pharmacy – returning to medicine's roots could help fill drug discovery gaps

With the dual threats of antibiotic resistance and emerging pandemics, finding new drugs becomes even more urgent. A trove of medicines may be lying under our nose.

Ashu Tripathi, Director, Natural Product Discovery Core; Assistant Professor/ Research of Medicinal Chemistry, University of Michigan • conversation
July 27, 2022 ~9 min

Many medications affect more than one target in the body – some drug designers are embracing the 'side effects' that had been seen as a drawback

Many approved drugs work on the body in ways that researchers still aren’t entirely clear about. Seeing this as an opportunity instead of a flaw may lead to better treatments for complex conditions.

Gregory Way, Assistant Professor of Biochemistry and Molecular Genetics, University of Colorado Anschutz Medical Campus • conversation
July 11, 2022 ~9 min


Discovering new drugs is a long and expensive process – chemical compounds that dupe screening tools make it even harder

While technological advancements have quickened the drug discovery process, some chemical compounds remain a common thorn in a researcher’s side.

Martin Clasby, Research Assistant Professor of Medicinal Chemistry, University of Michigan Medical School • conversation
April 21, 2022 ~6 min

The FDA's lax oversight of research in developing countries can do harm to vulnerable participants

Regulatory loopholes for research conducted off US soil allow for questionable trials and misleading data to slip under the FDA’s radar.

C. Michael White, Distinguished Professor and Head of the Department of Pharmacy Practice, University of Connecticut • conversation
Nov. 12, 2021 ~5 min

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