What’s in your medicine may surprise you – a call for greater transparency about inactive ingredients

There are ingredients in your pills other than the one designed to treat your ailments. Those unnamed ingredients can alter how you respond to a medicine or even make you sick.

Yelena Ionova, Postdoctoral Fellow in Quality of Medical Products, University of California, San Francisco • conversation
Sept. 11, 2020 ~7 min

Tags: drugs medicine generic-medicines generic-drugs patient-safety cares-act adverse-drug-reactions

When Trump pushed hydroxychloroquine to treat COVID-19, hundreds of thousands of prescriptions followed despite little evidence that it worked

When news reports tout a drug, people get interested, even if the benefits are unproven. Patient hopes, requests and demands can easily turn into real prescriptions in their doctor's office.

Richard L. Kravitz, Professor of Health Policy and Internal Medicine, University of California, Davis • conversation
July 9, 2020 ~10 min

Tags: drugs covid-19 coronavirus donald-trump hydroxychloroquine prescribing chloroquine medication prescription-drugs medications fox-news new-york-times doctor-prescribing off-label-prescribing

Coronavirus and cancer hijack the same parts in human cells to spread – and our team identified existing cancer drugs that could fight COVID-19

Kinases are cellular control switches. When they malfunction, they can cause cancer. The coronavirus hijacks these kinases to replicate, and cancer drugs that target them could fight COVID-19.

Nevan Krogan, Professor and Director of Quantitative Biosciences Institute & Senior Investigator at the Gladstone Institutes, University of California, San Francisco • conversation
June 28, 2020 ~10 min

Tags: drugs covid-19 coronavirus sars-cov-2 treatment antiviral-drugs drug-research sars-cov mass-spectrometry cancer-drugs antiviral

We found and tested 47 old drugs that might treat the coronavirus: Results show promising leads and a whole new way to fight COVID-19

Researchers at the University of California, San Francisco, identified nine existing drugs that show promise to treat COVID-19. The proteins they target haven't been tried before.

Nevan Krogan, Professor and Director of Quantitative Biosciences Institute & Senior Investigator at the Gladstone Institutes, University of California, San Francisco • conversation
April 30, 2020 ~10 min

Tags: drugs health drug-discovery covid-19 coronavirus rna fda sars-cov-2 viruses hydroxychloroquine cells progesterone treatments anti-virals

Coronavirus treatments: what drugs might work against COVID-19?

Coronavirus drug trials are underway – a virologist explains what the treatment options may be.

Connor Bamford, Research Fellow, Virology, Queen's University Belfast • conversation
April 16, 2020 ~6 min

Tags: drugs covid-19 pandemic vaccines covid-19-testing hydroxychloroquine chloroquine immunisation

Coronavirus research done too fast is testing publishing safeguards, bad science is getting through

Researchers, scientific journals and health agencies are doing everything they can to speed up coronavirus research. The combination of pace and panic during this pandemic is causing mistakes.

Irving Steinberg, Dean for Faculty, USC School of Pharmacy; Associate Professor of Clinical Pharmacy & Pediatrics, School of Pharmacy & Keck School of Medicine of USC; Director, Division of Pediatric Pharmacotherapy, Dept of Pediatrics, LAC+USC Med • conversation
April 9, 2020 ~9 min

Tags: drugs covid-19 coronavirus science ibuprofen world-health-organization-who hydroxychloroquine peer-review scientific-method

Medical supply chains are fragile in the best of times and COVID-19 will test their strength

Drug shortages occur regularly in the US, even in the best of times. The pharmaceutical supply chain embodies 'just in time' shipping and has little built-in redundancy.

Mark Daskin, Professor of Industrial and Operations Engineering, University of Michigan • conversation
March 25, 2020 ~7 min

Tags:  drugs  pharmaceuticals  supply-chains  regulation  regulations  medicines  generic-medicines  generic-drugs  pharmaceutical-industry  medical-supply-chains

COVID-19 treatment might already exist in old drugs – we're using pieces of the coronavirus itself to find them

Among the more than 20,000 drugs approved by the FDA, there may be some that can treat COVID-19. A team at the University of California, San Francisco, is identifying possible candidates.

Nevan Krogan, Professor and Director of Quantitative Biosciences Institute, University of California, San Francisco • conversation
March 20, 2020 ~8 min

Tags:  drugs  drug-discovery  covid-19  coronavirus  fda  sars-cov-2  treatment  disease  antiviral-drugs  viruses  viral-infections  drug-research

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