Immune health is all about balance – an immunologist explains why both too strong and too weak an immune response can lead to illness

Dietary supplements claim to be able to ‘boost your immune system’ to combat disease. But attaining immune balance through a healthy lifestyle and vaccination is a safer bet to keep in good health.

Aimee Pugh Bernard, Assistant Professor of Immunology and Microbiology, University of Colorado Anschutz Medical Campus • conversation
Nov. 20, 2023 ~6 min

Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research

T cells recognize and kill cancer cells but quickly lose their effectiveness. This fast dysfunction may help explain why immunotherapy doesn’t lead to long-term remission for many patients.

Michael Rudloff, MD-Ph.D. Candidate in Molecular Pathology and Immunology, Vanderbilt University • conversation
Aug. 3, 2023 ~6 min


Immune cells in the brain may reduce damage during seizures and promote recovery, according to study in mice

Seizures are like sudden electrical storms in the brain that can cause lasting damage. A set of immune cells in the brain called microglia may provide protection.

Synphane Gibbs-Shelton, Ph.D. Candidate in Pharmacology, University of Virginia • conversation
July 11, 2023 ~3 min

Harnessing the brain's immune cells to stave off Alzheimer's and other neurodegenerative diseases

Microglia, immune cells disguised as brain cells, are known as the janitors of the brain. Dialing up their usual duties just enough could provide an avenue to treat neurodegenerative disease.

Kristine Zengeler, Ph.D. Candidate in Neuroscience, University of Virginia • conversation
Dec. 7, 2022 ~9 min

What is inflammation? Two immunologists explain how the body responds to everything from stings to vaccination and why it sometimes goes wrong

Inflammation is a complicated and important part of how the immune system responds to threats to the body. But when the inflammatory response goes awry, it can lead to serious problems.

Mitzi Nagarkatti, Professor of Pathology, Microbiology and Immunology, University of South Carolina • conversation
Nov. 7, 2022 ~6 min

Long COVID-19 and other chronic respiratory conditions after viral infections may stem from an overactive immune response in the lungs

While a strong immune response is essential to fight against viral infection, an immune system that continues to stay active long after the virus has been cleared can lead to lung damage.

Harish Narasimhan, PhD Candidate in Immunology, University of Virginia • conversation
Aug. 4, 2022 ~7 min

Sepsis still kills 1 in 5 people worldwide – two ICU physicians offer a new approach to stopping it

Sepsis onset can be difficult to recognize, in part because its symptoms can mimic those of many other conditions. A treatment delay of even a few hours can make the difference between life and death.

Kristina E. Rudd, Assistant Professor of Critical Care Medicine, University of Pittsburgh Health Sciences • conversation
June 10, 2022 ~10 min

How mRNA and DNA vaccines could soon treat cancers, HIV, autoimmune disorders and genetic diseases

DNA and mRNA vaccines produce a different kind of immune response than traditional vaccines, allowing researchers to tackle some previously unsolvable problems in medicine.

Deborah Fuller, Professor of Microbiology, School of Medicine, University of Washington • conversation
Jan. 24, 2022 ~9 min


Specialized cells maintain healthy pregnancy by teaching the mother's immune system not to attack developing fetus

How the immune system learns not to attack a developing fetus and placenta is important to understanding pregnancy and its common complications, like miscarriage.

Tippi MacKenzie, Professor of Surgery, University of California, San Francisco • conversation
Aug. 25, 2021 ~5 min

Do I need a COVID-19 booster shot? 6 questions answered on how to stay protected

Though currently approved COVID-19 vaccines effectively provide immunity against the virus, it's unclear how long that protection will last.

William Petri, Professor of Medicine, University of Virginia • conversation
July 8, 2021 ~7 min

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