Immune cells can adapt to invading pathogens, deciding whether to fight now or prepare for the next battle

When faced with a threat, T cells have the decision-making flexibility to both clear out the pathogen now and ready themselves for a future encounter.

Hao Yuan Kueh, Associate Professor of Bioengineering, University of Washington • conversation
March 8, 2024 ~6 min

Immune health is all about balance – an immunologist explains why both too strong and too weak an immune response can lead to illness

Dietary supplements claim to be able to ‘boost your immune system’ to combat disease. But attaining immune balance through a healthy lifestyle and vaccination is a safer bet to keep in good health.

Aimee Pugh Bernard, Assistant Professor of Immunology and Microbiology, University of Colorado Anschutz Medical Campus • conversation
Nov. 20, 2023 ~6 min


Immune cells that fight cancer become exhausted within hours of first encountering tumors – new research

T cells recognize and kill cancer cells but quickly lose their effectiveness. This fast dysfunction may help explain why immunotherapy doesn’t lead to long-term remission for many patients.

Michael Rudloff, MD-Ph.D. Candidate in Molecular Pathology and Immunology, Vanderbilt University • conversation
Aug. 3, 2023 ~6 min

Asymptomatic COVID-19 is linked to a gene variant that boosts immune memory after exposure to prior seasonal cold viruses

Researchers found that people with a specific gene variant were two to eight times more likely to not have symptoms after infection.

Danillo Augusto, Assistant Professor of Biological Sciences, University of North Carolina – Charlotte • conversation
July 19, 2023 ~5 min

Moderna's experimental cancer vaccine treats but doesn't prevent melanoma – a biochemist explains how it works

Preventive and therapeutic vaccines both train the immune system to fight disease, but they are used in different ways.

Mark R. O'Brian, Professor and Chair of Biochemistry, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo • conversation
Jan. 17, 2023 ~8 min

Anti-cancer CAR-T therapy reengineers T cells to kill tumors – and researchers are expanding the limited types of cancer it can target

Immunotherapy has the potential to eliminate tumors, but works best for select patients. Engineering T cells to bypass cancer’s defenses could help expand treatment eligibility to more patients.

Gregory Allen, Assistant Professor of Medicine, University of California, San Francisco • conversation
Dec. 15, 2022 ~8 min

What is inflammation? Two immunologists explain how the body responds to everything from stings to vaccination and why it sometimes goes wrong

Inflammation is a complicated and important part of how the immune system responds to threats to the body. But when the inflammatory response goes awry, it can lead to serious problems.

Mitzi Nagarkatti, Professor of Pathology, Microbiology and Immunology, University of South Carolina • conversation
Nov. 7, 2022 ~6 min

Gut bacteria nurture the immune system – for cancer patients, a diverse microbiome can protect against dangerous treatment complications

Patients with blood cancer undergoing stem cell transplantation have a high risk of complications. The bacteria in their gut, however, can help their immune system recover and fight infections.

Kate Ann Markey, Assistant Professor of Medical Oncology, University of Washington • conversation
July 13, 2022 ~7 min


Social stress can speed up immune system aging – new research

While the immune system naturally gets weaker with age, social stressors like trauma and discrimination can hasten immunosenescence.

Eric Klopack, Postdoctoral Researcher in Gerontology, University of Southern California • conversation
June 15, 2022 ~6 min

'Masked' cancer drug stealthily trains immune system to kill tumors while sparing healthy tissues, reducing treatment side effects

One promising cancer treatment has been in the works for decades, but severe side effects have kept it out of the clinic. A reengineered version may offer a way to safely harness its potent effects.

Aslan Mansurov, Postdoctoral Researcher in Molecular Engineering, University of Chicago Pritzker School of Molecular Engineering • conversation
June 1, 2022 ~5 min

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